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Dezipramine Brand names, Dezipramine Analogs

Dezipramine Brand Names Mixture

  • No information avaliable

Dezipramine Chemical_Formula


Dezipramine RX_link

Dezipramine fda sheet

Dezipramine FDA

Dezipramine msds (material safety sheet)

Dezipramine MSDS

Dezipramine Synthesis Reference

No information avaliable

Dezipramine Molecular Weight

266.381 g/mol

Dezipramine Melting Point

214-218 oC

Dezipramine H2O Solubility

No information avaliable

Dezipramine State


Dezipramine LogP


Dezipramine Dosage Forms


Dezipramine Indication

For relief of symptoms in various depressive syndromes, especially endogenous depression.

Dezipramine Pharmacology

Desipramine, a tertiary amine tricyclic antidepressant, is structurally related to both the skeletal muscle relaxant cyclobenzaprine and the thioxanthene antipsychotics such as thiothixene. Desipramine is used to treat depression, pain of neuropathic origin, attention_deficit hyperactivity disorder, functional enuresis in children, panic and phobic disorder, and to manage some eating disorders. Desipramine inhibits the re-uptake of noradrenaline at the noradrenergic nerve endings and the re-uptake of serotonin (5-hydroxy tryptamine) at the serotoninergic nerve endings in the central nervous system. These two effects are considered to be the likely base of the antidepressant effect of Desipramine. The drug also has a strong anticholinergic effect and serves as an antagonist on a1 and H1 receptors.

Dezipramine Absorption

Desipramine hydrochloride is rapidly and almost completely absorbed from the gastrointestinal tract. 90.5% (range 73-92%) of desipramine binds to plasma proteins.

Dezipramine side effects and Toxicity

Male mice: LD50 = 290 mg/kg, female rats: LD50 = 320 mg/kg

Dezipramine Patient Information

No information avaliable

Dezipramine Organisms Affected

Humans and other mammals