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Desimpramine Brand names, Desimpramine Analogs

Desimpramine Brand Names Mixture

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Desimpramine Chemical_Formula


Desimpramine RX_link

Desimpramine fda sheet

Desimpramine FDA

Desimpramine msds (material safety sheet)

Desimpramine MSDS

Desimpramine Synthesis Reference

No information avaliable

Desimpramine Molecular Weight

266.381 g/mol

Desimpramine Melting Point

214-218 oC

Desimpramine H2O Solubility

No information avaliable

Desimpramine State


Desimpramine LogP


Desimpramine Dosage Forms


Desimpramine Indication

For relief of symptoms in various depressive syndromes, especially endogenous depression.

Desimpramine Pharmacology

Desipramine, a tertiary amine tricyclic antidepressant, is structurally related to both the skeletal muscle relaxant cyclobenzaprine and the thioxanthene antipsychotics such as thiothixene. Desipramine is used to treat depression, pain of neuropathic origin, attention_deficit hyperactivity disorder, functional enuresis in children, panic and phobic disorder, and to manage some eating disorders. Desipramine inhibits the re-uptake of noradrenaline at the noradrenergic nerve endings and the re-uptake of serotonin (5-hydroxy tryptamine) at the serotoninergic nerve endings in the central nervous system. These two effects are considered to be the likely base of the antidepressant effect of Desipramine. The drug also has a strong anticholinergic effect and serves as an antagonist on a1 and H1 receptors.

Desimpramine Absorption

Desipramine hydrochloride is rapidly and almost completely absorbed from the gastrointestinal tract. 90.5% (range 73-92%) of desipramine binds to plasma proteins.

Desimpramine side effects and Toxicity

Male mice: LD50 = 290 mg/kg, female rats: LD50 = 320 mg/kg

Desimpramine Patient Information

No information avaliable

Desimpramine Organisms Affected

Humans and other mammals