DMI
DMI Brand names, DMI Analogs
DMI Brand Names Mixture
- No information avaliable
DMI Chemical_Formula
C18H22N2
DMI RX_link
http://www.rxlist.com/cgi/generic2/desipram.htm
DMI fda sheet
DMI msds (material safety sheet)
DMI Synthesis Reference
No information avaliable
DMI Molecular Weight
266.381 g/mol
DMI Melting Point
214-218 oC
DMI H2O Solubility
No information avaliable
DMI State
Solid
DMI LogP
3.87
DMI Dosage Forms
Tablet
DMI Indication
For relief of symptoms in various depressive syndromes, especially endogenous depression.
DMI Pharmacology
Desipramine, a tertiary amine tricyclic antidepressant, is structurally related to both the skeletal muscle relaxant cyclobenzaprine and the thioxanthene antipsychotics such as thiothixene. Desipramine is used to treat depression, pain of neuropathic origin, attention_deficit hyperactivity disorder, functional enuresis in children, panic and phobic disorder, and to manage some eating disorders. Desipramine inhibits the re-uptake of noradrenaline at the noradrenergic nerve endings and the re-uptake of serotonin (5-hydroxy tryptamine) at the serotoninergic nerve endings in the central nervous system. These two effects are considered to be the likely base of the antidepressant effect of Desipramine. The drug also has a strong anticholinergic effect and serves as an antagonist on a1 and H1 receptors.
DMI Absorption
Desipramine hydrochloride is rapidly and almost completely absorbed from the gastrointestinal tract. 90.5% (range 73-92%) of desipramine binds to plasma proteins.
DMI side effects and Toxicity
Male mice: LD50 = 290 mg/kg, female rats: LD50 = 320 mg/kg
DMI Patient Information
No information avaliable
DMI Organisms Affected
Humans and other mammals
