None

None Brand names, None Analogs

None Brand Names Mixture

No information avaliable

None Chemical_Formula

C₁₇H₂₁NO₄

None RX_link

http://www.rxlist.com/cgi/generic/cocaine.htm

None fda sheet

None msds (material safety sheet)

None MSDS

None Synthesis Reference

No information avaliable

None Molecular Weight

303.353 g/mol

None Melting Point

195 ^oC

None H₂O Solubility

1800 mg/L

None State

Solid

None LogP

2.393

None Dosage Forms

Liquid

None Indication

For the introduction of local (topical) anesthesia of accessible mucous membranes of the oral, laryngeal and nasal cavities.

None Pharmacology

Cocaine is a local anesthetic indicated for the introduction of local (topical) anesthesia of accessible mucous membranes of the oral, laryngeal and nasal cavities.

None Absorption

Cocaine is absorbed from all sites of application, including mucous membranes and gastrointestinal mucosa. By oral or intra-nasal route, 60 to 80% of cocaine is absorbed.

None side effects and Toxicity

Intense agitation, convulsions, hypertension, rhythm disturbance, coronary insufficiency, hyperthermia, rhabdomyolysis, and renal impairment. Oral mouse LD₅₀ = 96 mg/kg

None Patient Information