Ecgonine, Methyl Ester, Benzoate
Brand names,
Ecgonine, Methyl Ester, Benzoate
Analogs
Ecgonine, Methyl Ester, Benzoate
Brand Names Mixture
Ecgonine, Methyl Ester, Benzoate
Chemical_Formula
C17H21NO4
Ecgonine, Methyl Ester, Benzoate
RX_link
http://www.rxlist.com/cgi/generic/cocaine.htm
Ecgonine, Methyl Ester, Benzoate
fda sheet
Ecgonine, Methyl Ester, Benzoate
msds (material safety sheet)
Ecgonine, Methyl Ester, Benzoate
Synthesis Reference
No information avaliable
Ecgonine, Methyl Ester, Benzoate
Molecular Weight
303.353 g/mol
Ecgonine, Methyl Ester, Benzoate
Melting Point
195 oC
Ecgonine, Methyl Ester, Benzoate
H2O Solubility
1800 mg/L
Ecgonine, Methyl Ester, Benzoate
State
Solid
Ecgonine, Methyl Ester, Benzoate
LogP
2.393
Ecgonine, Methyl Ester, Benzoate
Dosage Forms
Liquid
Ecgonine, Methyl Ester, Benzoate
Indication
For the introduction of local (topical) anesthesia of accessible mucous membranes of the oral, laryngeal and nasal cavities.
Ecgonine, Methyl Ester, Benzoate
Pharmacology
Cocaine is a local anesthetic indicated for the introduction of local (topical) anesthesia of accessible mucous membranes of the oral, laryngeal and nasal cavities.
Ecgonine, Methyl Ester, Benzoate
Absorption
Cocaine is absorbed from all sites of application, including mucous membranes and gastrointestinal mucosa. By oral or intra-nasal route, 60 to 80% of cocaine is absorbed.
Ecgonine, Methyl Ester, Benzoate
side effects and Toxicity
Intense agitation, convulsions, hypertension, rhythm disturbance, coronary insufficiency, hyperthermia, rhabdomyolysis, and renal impairment. Oral mouse LD50 = 96 mg/kg
Ecgonine, Methyl Ester, Benzoate
Patient Information
No information avaliable
Ecgonine, Methyl Ester, Benzoate
Organisms Affected
Humans and other mammals