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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C17H21NO4
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RX_link
http://www.rxlist.com/cgi/generic/cocaine.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
No information avaliable
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Molecular Weight
303.353 g/mol
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Melting Point
195 oC
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H2O Solubility
1800 mg/L
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State
Solid
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LogP
2.393
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Dosage Forms
Liquid
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Indication
For the introduction of local (topical) anesthesia of accessible mucous membranes of the oral, laryngeal and nasal cavities.
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Pharmacology
Cocaine is a local anesthetic indicated for the introduction of local (topical) anesthesia of accessible mucous membranes of the oral, laryngeal and nasal cavities.
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Absorption
Cocaine is absorbed from all sites of application, including mucous membranes and gastrointestinal mucosa. By oral or intra-nasal route, 60 to 80% of cocaine is absorbed.
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side effects and Toxicity
Intense agitation, convulsions, hypertension, rhythm disturbance, coronary insufficiency, hyperthermia, rhabdomyolysis, and renal impairment. Oral mouse LD50 = 96 mg/kg
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Patient Information
No information avaliable
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Organisms Affected
Humans and other mammals