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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C6H14FO3P
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RX_link
No information avaliable
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
No information avaliable
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Molecular Weight
184.146 g/mol
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Melting Point
-82 oC
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H2O Solubility
1.54E+004 mg/L
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State
Liquid
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LogP
1.13
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Dosage Forms
No information avaliable
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Indication
For use in the eye to treat certain types of glaucoma and other eye conditions, such as accommodative esotropia.
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Pharmacology
Isoflurophate is used as ocular drops in the treatment of chronic glaucoma. Isoflurophate is an organophosphorus compound that acts as an irreversible cholinesterase inhibitor. As such, it displays parasympathomimetic effects. Isoflurophate is used in the eye to treat certain types of glaucoma and other eye conditions, such as accommodative esotropia. They may also be used in the diagnosis of certain eye conditions, such as accommodative esotropia. Isoflurophate damages the acetylcholinesterase enzyme and is therefore irreversible, however, pralidoxime can displace organophosphates such as isoflurophate from acetylcholinesterase, but only if administered before isoflurophate damages (alkylates) the enzyme.
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Absorption
No information avaliable
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side effects and Toxicity
Signs of overdose include increased sweating, loss of bladder control, muscle weakness, nausea, vomiting, diarrhea, or stomach cramps or pain, shortness of breath, tightness in chest, or wheezing, slow or irregular heartbeat, unusual tiredness or weakness, watering of mouth.
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Patient Information
No information avaliable
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Organisms Affected
Humans and other mammals