Mitoxan
Mitoxan Brand names, Mitoxan Analogs
Mitoxan Brand Names Mixture
- No information avaliable
Mitoxan Chemical_Formula
C7H15Cl2N2O2P
Mitoxan RX_link
http://www.rxlist.com/cgi/generic2/ifosfamide.htm
Mitoxan fda sheet
Mitoxan msds (material safety sheet)
Mitoxan Synthesis Reference
No information avaliable
Mitoxan Molecular Weight
261.085 g/mol
Mitoxan Melting Point
39-41 oC
Mitoxan H2O Solubility
3780 mg/L
Mitoxan State
Solid
Mitoxan LogP
-0.01
Mitoxan Dosage Forms
Powder for constitution and administration by intravenous infusion
Mitoxan Indication
For third line chemotherapy of germ cell testicular cancer. It should ordinarily be used in combination with a prophylactic agent for hemorrhagic cystitis, such as mesna.
Mitoxan Pharmacology
Ifosfamide selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of ifosfamide-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed.
Mitoxan Absorption
No information avaliable
Mitoxan side effects and Toxicity
LD50 (mouse) = 390-1005 mg/kg, LD50 (rat) = 150-190 mg/kg. Side effects include nausea, vomiting and myelosuppression. Toxic effects include central nervous system toxicity (confusion, hallucinations) and urotoxic effects (cystitis, blood in urine).
Mitoxan Patient Information
No information avaliable
Mitoxan Organisms Affected
Humans and other mammals
