Ifex/Mesnex Kit
Ifex/Mesnex Kit Brand names, Ifex/Mesnex Kit Analogs
Ifex/Mesnex Kit Brand Names Mixture
- No information avaliable
Ifex/Mesnex Kit Chemical_Formula
C7H15Cl2N2O2P
Ifex/Mesnex Kit RX_link
http://www.rxlist.com/cgi/generic2/ifosfamide.htm
Ifex/Mesnex Kit fda sheet
Ifex/Mesnex Kit msds (material safety sheet)
Ifex/Mesnex Kit Synthesis Reference
No information avaliable
Ifex/Mesnex Kit Molecular Weight
261.085 g/mol
Ifex/Mesnex Kit Melting Point
39-41 oC
Ifex/Mesnex Kit H2O Solubility
3780 mg/L
Ifex/Mesnex Kit State
Solid
Ifex/Mesnex Kit LogP
-0.01
Ifex/Mesnex Kit Dosage Forms
Powder for constitution and administration by intravenous infusion
Ifex/Mesnex Kit Indication
For third line chemotherapy of germ cell testicular cancer. It should ordinarily be used in combination with a prophylactic agent for hemorrhagic cystitis, such as mesna.
Ifex/Mesnex Kit Pharmacology
Ifosfamide selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of ifosfamide-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed.
Ifex/Mesnex Kit Absorption
No information avaliable
Ifex/Mesnex Kit side effects and Toxicity
LD50 (mouse) = 390-1005 mg/kg, LD50 (rat) = 150-190 mg/kg. Side effects include nausea, vomiting and myelosuppression. Toxic effects include central nervous system toxicity (confusion, hallucinations) and urotoxic effects (cystitis, blood in urine).
Ifex/Mesnex Kit Patient Information
No information avaliable
Ifex/Mesnex Kit Organisms Affected
Humans and other mammals
