Ifosfamide Sterile
Ifosfamide Sterile Brand names, Ifosfamide Sterile Analogs
Ifosfamide Sterile Brand Names Mixture
- No information avaliable
Ifosfamide Sterile Chemical_Formula
C7H15Cl2N2O2P
Ifosfamide Sterile RX_link
http://www.rxlist.com/cgi/generic2/ifosfamide.htm
Ifosfamide Sterile fda sheet
Ifosfamide Sterile msds (material safety sheet)
Ifosfamide Sterile Synthesis Reference
No information avaliable
Ifosfamide Sterile Molecular Weight
261.085 g/mol
Ifosfamide Sterile Melting Point
39-41 oC
Ifosfamide Sterile H2O Solubility
3780 mg/L
Ifosfamide Sterile State
Solid
Ifosfamide Sterile LogP
-0.01
Ifosfamide Sterile Dosage Forms
Powder for constitution and administration by intravenous infusion
Ifosfamide Sterile Indication
For third line chemotherapy of germ cell testicular cancer. It should ordinarily be used in combination with a prophylactic agent for hemorrhagic cystitis, such as mesna.
Ifosfamide Sterile Pharmacology
Ifosfamide selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of ifosfamide-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed.
Ifosfamide Sterile Absorption
No information avaliable
Ifosfamide Sterile side effects and Toxicity
LD50 (mouse) = 390-1005 mg/kg, LD50 (rat) = 150-190 mg/kg. Side effects include nausea, vomiting and myelosuppression. Toxic effects include central nervous system toxicity (confusion, hallucinations) and urotoxic effects (cystitis, blood in urine).
Ifosfamide Sterile Patient Information
No information avaliable
Ifosfamide Sterile Organisms Affected
Humans and other mammals
