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Isophosphamide Brand names, Isophosphamide Analogs

Isophosphamide Brand Names Mixture

  • No information avaliable

Isophosphamide Chemical_Formula


Isophosphamide RX_link

Isophosphamide fda sheet

Isophosphamide msds (material safety sheet)

Isophosphamide MSDS

Isophosphamide Synthesis Reference

No information avaliable

Isophosphamide Molecular Weight

261.085 g/mol

Isophosphamide Melting Point

39-41 oC

Isophosphamide H2O Solubility

3780 mg/L

Isophosphamide State


Isophosphamide LogP


Isophosphamide Dosage Forms

Powder for constitution and administration by intravenous infusion

Isophosphamide Indication

For third line chemotherapy of germ cell testicular cancer. It should ordinarily be used in combination with a prophylactic agent for hemorrhagic cystitis, such as mesna.

Isophosphamide Pharmacology

Ifosfamide selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of ifosfamide-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed.

Isophosphamide Absorption

No information avaliable

Isophosphamide side effects and Toxicity

LD50 (mouse) = 390-1005 mg/kg, LD50 (rat) = 150-190 mg/kg. Side effects include nausea, vomiting and myelosuppression. Toxic effects include central nervous system toxicity (confusion, hallucinations) and urotoxic effects (cystitis, blood in urine).

Isophosphamide Patient Information

No information avaliable

Isophosphamide Organisms Affected

Humans and other mammals