Isophosphamide
Isophosphamide Brand names, Isophosphamide Analogs
Isophosphamide Brand Names Mixture
- No information avaliable
Isophosphamide Chemical_Formula
C7H15Cl2N2O2P
Isophosphamide RX_link
http://www.rxlist.com/cgi/generic2/ifosfamide.htm
Isophosphamide fda sheet
Isophosphamide msds (material safety sheet)
Isophosphamide Synthesis Reference
No information avaliable
Isophosphamide Molecular Weight
261.085 g/mol
Isophosphamide Melting Point
39-41 oC
Isophosphamide H2O Solubility
3780 mg/L
Isophosphamide State
Solid
Isophosphamide LogP
-0.01
Isophosphamide Dosage Forms
Powder for constitution and administration by intravenous infusion
Isophosphamide Indication
For third line chemotherapy of germ cell testicular cancer. It should ordinarily be used in combination with a prophylactic agent for hemorrhagic cystitis, such as mesna.
Isophosphamide Pharmacology
Ifosfamide selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of ifosfamide-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed.
Isophosphamide Absorption
No information avaliable
Isophosphamide side effects and Toxicity
LD50 (mouse) = 390-1005 mg/kg, LD50 (rat) = 150-190 mg/kg. Side effects include nausea, vomiting and myelosuppression. Toxic effects include central nervous system toxicity (confusion, hallucinations) and urotoxic effects (cystitis, blood in urine).
Isophosphamide Patient Information
No information avaliable
Isophosphamide Organisms Affected
Humans and other mammals
