PharmacyCodes



I-Phosphamide en es it fr

I-Phosphamide Brand names, I-Phosphamide Analogs

I-Phosphamide Brand Names Mixture

  • No information avaliable

I-Phosphamide Chemical_Formula

C7H15Cl2N2O2P

I-Phosphamide RX_link

http://www.rxlist.com/cgi/generic2/ifosfamide.htm

I-Phosphamide fda sheet

http://www.accessdata.fda.gov/scripts/cder/onctools/summary.cfm?ID=95

I-Phosphamide msds (material safety sheet)

I-Phosphamide MSDS

I-Phosphamide Synthesis Reference

No information avaliable

I-Phosphamide Molecular Weight

261.085 g/mol

I-Phosphamide Melting Point

39-41 oC

I-Phosphamide H2O Solubility

3780 mg/L

I-Phosphamide State

Solid

I-Phosphamide LogP

-0.01

I-Phosphamide Dosage Forms

Powder for constitution and administration by intravenous infusion

I-Phosphamide Indication

For third line chemotherapy of germ cell testicular cancer. It should ordinarily be used in combination with a prophylactic agent for hemorrhagic cystitis, such as mesna.

I-Phosphamide Pharmacology

Ifosfamide selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of ifosfamide-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed.

I-Phosphamide Absorption

No information avaliable

I-Phosphamide side effects and Toxicity

LD50 (mouse) = 390-1005 mg/kg, LD50 (rat) = 150-190 mg/kg. Side effects include nausea, vomiting and myelosuppression. Toxic effects include central nervous system toxicity (confusion, hallucinations) and urotoxic effects (cystitis, blood in urine).

I-Phosphamide Patient Information

No information avaliable

I-Phosphamide Organisms Affected

Humans and other mammals