IFEX
IFEX Brand names, IFEX Analogs
IFEX Brand Names Mixture
- No information avaliable
IFEX Chemical_Formula
C7H15Cl2N2O2P
IFEX RX_link
http://www.rxlist.com/cgi/generic2/ifosfamide.htm
IFEX fda sheet
IFEX msds (material safety sheet)
IFEX Synthesis Reference
No information avaliable
IFEX Molecular Weight
261.085 g/mol
IFEX Melting Point
39-41 oC
IFEX H2O Solubility
3780 mg/L
IFEX State
Solid
IFEX LogP
-0.01
IFEX Dosage Forms
Powder for constitution and administration by intravenous infusion
IFEX Indication
For third line chemotherapy of germ cell testicular cancer. It should ordinarily be used in combination with a prophylactic agent for hemorrhagic cystitis, such as mesna.
IFEX Pharmacology
Ifosfamide selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of ifosfamide-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed.
IFEX Absorption
No information avaliable
IFEX side effects and Toxicity
LD50 (mouse) = 390-1005 mg/kg, LD50 (rat) = 150-190 mg/kg. Side effects include nausea, vomiting and myelosuppression. Toxic effects include central nervous system toxicity (confusion, hallucinations) and urotoxic effects (cystitis, blood in urine).
IFEX Patient Information
No information avaliable
IFEX Organisms Affected
Humans and other mammals
