Cyfos
Cyfos Brand names, Cyfos Analogs
Cyfos Brand Names Mixture
- No information avaliable
Cyfos Chemical_Formula
C7H15Cl2N2O2P
Cyfos RX_link
http://www.rxlist.com/cgi/generic2/ifosfamide.htm
Cyfos fda sheet
Cyfos msds (material safety sheet)
Cyfos Synthesis Reference
No information avaliable
Cyfos Molecular Weight
261.085 g/mol
Cyfos Melting Point
39-41 oC
Cyfos H2O Solubility
3780 mg/L
Cyfos State
Solid
Cyfos LogP
-0.01
Cyfos Dosage Forms
Powder for constitution and administration by intravenous infusion
Cyfos Indication
For third line chemotherapy of germ cell testicular cancer. It should ordinarily be used in combination with a prophylactic agent for hemorrhagic cystitis, such as mesna.
Cyfos Pharmacology
Ifosfamide selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of ifosfamide-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed.
Cyfos Absorption
No information avaliable
Cyfos side effects and Toxicity
LD50 (mouse) = 390-1005 mg/kg, LD50 (rat) = 150-190 mg/kg. Side effects include nausea, vomiting and myelosuppression. Toxic effects include central nervous system toxicity (confusion, hallucinations) and urotoxic effects (cystitis, blood in urine).
Cyfos Patient Information
No information avaliable
Cyfos Organisms Affected
Humans and other mammals
