Ifsofamide
Ifsofamide Brand names, Ifsofamide Analogs
Ifsofamide Brand Names Mixture
- No information avaliable
Ifsofamide Chemical_Formula
C7H15Cl2N2O2P
Ifsofamide RX_link
http://www.rxlist.com/cgi/generic2/ifosfamide.htm
Ifsofamide fda sheet
Ifsofamide msds (material safety sheet)
Ifsofamide Synthesis Reference
No information avaliable
Ifsofamide Molecular Weight
261.085 g/mol
Ifsofamide Melting Point
39-41 oC
Ifsofamide H2O Solubility
3780 mg/L
Ifsofamide State
Solid
Ifsofamide LogP
-0.01
Ifsofamide Dosage Forms
Powder for constitution and administration by intravenous infusion
Ifsofamide Indication
For third line chemotherapy of germ cell testicular cancer. It should ordinarily be used in combination with a prophylactic agent for hemorrhagic cystitis, such as mesna.
Ifsofamide Pharmacology
Ifosfamide selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of ifosfamide-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed.
Ifsofamide Absorption
No information avaliable
Ifsofamide side effects and Toxicity
LD50 (mouse) = 390-1005 mg/kg, LD50 (rat) = 150-190 mg/kg. Side effects include nausea, vomiting and myelosuppression. Toxic effects include central nervous system toxicity (confusion, hallucinations) and urotoxic effects (cystitis, blood in urine).
Ifsofamide Patient Information
No information avaliable
Ifsofamide Organisms Affected
Humans and other mammals
