Asta Z 4942
Asta Z 4942 Brand names, Asta Z 4942 Analogs
Asta Z 4942 Brand Names Mixture
- No information avaliable
Asta Z 4942 Chemical_Formula
C7H15Cl2N2O2P
Asta Z 4942 RX_link
http://www.rxlist.com/cgi/generic2/ifosfamide.htm
Asta Z 4942 fda sheet
Asta Z 4942 msds (material safety sheet)
Asta Z 4942 Synthesis Reference
No information avaliable
Asta Z 4942 Molecular Weight
261.085 g/mol
Asta Z 4942 Melting Point
39-41 oC
Asta Z 4942 H2O Solubility
3780 mg/L
Asta Z 4942 State
Solid
Asta Z 4942 LogP
-0.01
Asta Z 4942 Dosage Forms
Powder for constitution and administration by intravenous infusion
Asta Z 4942 Indication
For third line chemotherapy of germ cell testicular cancer. It should ordinarily be used in combination with a prophylactic agent for hemorrhagic cystitis, such as mesna.
Asta Z 4942 Pharmacology
Ifosfamide selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of ifosfamide-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed.
Asta Z 4942 Absorption
No information avaliable
Asta Z 4942 side effects and Toxicity
LD50 (mouse) = 390-1005 mg/kg, LD50 (rat) = 150-190 mg/kg. Side effects include nausea, vomiting and myelosuppression. Toxic effects include central nervous system toxicity (confusion, hallucinations) and urotoxic effects (cystitis, blood in urine).
Asta Z 4942 Patient Information
No information avaliable
Asta Z 4942 Organisms Affected
Humans and other mammals
