Mitoxana
Mitoxana Brand names, Mitoxana Analogs
Mitoxana Brand Names Mixture
- No information avaliable
Mitoxana Chemical_Formula
C7H15Cl2N2O2P
Mitoxana RX_link
http://www.rxlist.com/cgi/generic2/ifosfamide.htm
Mitoxana fda sheet
Mitoxana msds (material safety sheet)
Mitoxana Synthesis Reference
No information avaliable
Mitoxana Molecular Weight
261.085 g/mol
Mitoxana Melting Point
39-41 oC
Mitoxana H2O Solubility
3780 mg/L
Mitoxana State
Solid
Mitoxana LogP
-0.01
Mitoxana Dosage Forms
Powder for constitution and administration by intravenous infusion
Mitoxana Indication
For third line chemotherapy of germ cell testicular cancer. It should ordinarily be used in combination with a prophylactic agent for hemorrhagic cystitis, such as mesna.
Mitoxana Pharmacology
Ifosfamide selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of ifosfamide-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed.
Mitoxana Absorption
No information avaliable
Mitoxana side effects and Toxicity
LD50 (mouse) = 390-1005 mg/kg, LD50 (rat) = 150-190 mg/kg. Side effects include nausea, vomiting and myelosuppression. Toxic effects include central nervous system toxicity (confusion, hallucinations) and urotoxic effects (cystitis, blood in urine).
Mitoxana Patient Information
No information avaliable
Mitoxana Organisms Affected
Humans and other mammals
