Naxamide
Naxamide Brand names, Naxamide Analogs
Naxamide Brand Names Mixture
- No information avaliable
Naxamide Chemical_Formula
C7H15Cl2N2O2P
Naxamide RX_link
http://www.rxlist.com/cgi/generic2/ifosfamide.htm
Naxamide fda sheet
Naxamide msds (material safety sheet)
Naxamide Synthesis Reference
No information avaliable
Naxamide Molecular Weight
261.085 g/mol
Naxamide Melting Point
39-41 oC
Naxamide H2O Solubility
3780 mg/L
Naxamide State
Solid
Naxamide LogP
-0.01
Naxamide Dosage Forms
Powder for constitution and administration by intravenous infusion
Naxamide Indication
For third line chemotherapy of germ cell testicular cancer. It should ordinarily be used in combination with a prophylactic agent for hemorrhagic cystitis, such as mesna.
Naxamide Pharmacology
Ifosfamide selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of ifosfamide-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed.
Naxamide Absorption
No information avaliable
Naxamide side effects and Toxicity
LD50 (mouse) = 390-1005 mg/kg, LD50 (rat) = 150-190 mg/kg. Side effects include nausea, vomiting and myelosuppression. Toxic effects include central nervous system toxicity (confusion, hallucinations) and urotoxic effects (cystitis, blood in urine).
Naxamide Patient Information
No information avaliable
Naxamide Organisms Affected
Humans and other mammals
