Isofosfamide
Isofosfamide Brand names, Isofosfamide Analogs
Isofosfamide Brand Names Mixture
- No information avaliable
Isofosfamide Chemical_Formula
C7H15Cl2N2O2P
Isofosfamide RX_link
http://www.rxlist.com/cgi/generic2/ifosfamide.htm
Isofosfamide fda sheet
Isofosfamide msds (material safety sheet)
Isofosfamide Synthesis Reference
No information avaliable
Isofosfamide Molecular Weight
261.085 g/mol
Isofosfamide Melting Point
39-41 oC
Isofosfamide H2O Solubility
3780 mg/L
Isofosfamide State
Solid
Isofosfamide LogP
-0.01
Isofosfamide Dosage Forms
Powder for constitution and administration by intravenous infusion
Isofosfamide Indication
For third line chemotherapy of germ cell testicular cancer. It should ordinarily be used in combination with a prophylactic agent for hemorrhagic cystitis, such as mesna.
Isofosfamide Pharmacology
Ifosfamide selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of ifosfamide-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed.
Isofosfamide Absorption
No information avaliable
Isofosfamide side effects and Toxicity
LD50 (mouse) = 390-1005 mg/kg, LD50 (rat) = 150-190 mg/kg. Side effects include nausea, vomiting and myelosuppression. Toxic effects include central nervous system toxicity (confusion, hallucinations) and urotoxic effects (cystitis, blood in urine).
Isofosfamide Patient Information
No information avaliable
Isofosfamide Organisms Affected
Humans and other mammals
