Isoendoxan
Isoendoxan Brand names, Isoendoxan Analogs
Isoendoxan Brand Names Mixture
- No information avaliable
Isoendoxan Chemical_Formula
C7H15Cl2N2O2P
Isoendoxan RX_link
http://www.rxlist.com/cgi/generic2/ifosfamide.htm
Isoendoxan fda sheet
Isoendoxan msds (material safety sheet)
Isoendoxan Synthesis Reference
No information avaliable
Isoendoxan Molecular Weight
261.085 g/mol
Isoendoxan Melting Point
39-41 oC
Isoendoxan H2O Solubility
3780 mg/L
Isoendoxan State
Solid
Isoendoxan LogP
-0.01
Isoendoxan Dosage Forms
Powder for constitution and administration by intravenous infusion
Isoendoxan Indication
For third line chemotherapy of germ cell testicular cancer. It should ordinarily be used in combination with a prophylactic agent for hemorrhagic cystitis, such as mesna.
Isoendoxan Pharmacology
Ifosfamide selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of ifosfamide-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed.
Isoendoxan Absorption
No information avaliable
Isoendoxan side effects and Toxicity
LD50 (mouse) = 390-1005 mg/kg, LD50 (rat) = 150-190 mg/kg. Side effects include nausea, vomiting and myelosuppression. Toxic effects include central nervous system toxicity (confusion, hallucinations) and urotoxic effects (cystitis, blood in urine).
Isoendoxan Patient Information
No information avaliable
Isoendoxan Organisms Affected
Humans and other mammals
