Holoxan 1000
Holoxan 1000 Brand names, Holoxan 1000 Analogs
Holoxan 1000 Brand Names Mixture
- No information avaliable
Holoxan 1000 Chemical_Formula
C7H15Cl2N2O2P
Holoxan 1000 RX_link
http://www.rxlist.com/cgi/generic2/ifosfamide.htm
Holoxan 1000 fda sheet
Holoxan 1000 msds (material safety sheet)
Holoxan 1000 Synthesis Reference
No information avaliable
Holoxan 1000 Molecular Weight
261.085 g/mol
Holoxan 1000 Melting Point
39-41 oC
Holoxan 1000 H2O Solubility
3780 mg/L
Holoxan 1000 State
Solid
Holoxan 1000 LogP
-0.01
Holoxan 1000 Dosage Forms
Powder for constitution and administration by intravenous infusion
Holoxan 1000 Indication
For third line chemotherapy of germ cell testicular cancer. It should ordinarily be used in combination with a prophylactic agent for hemorrhagic cystitis, such as mesna.
Holoxan 1000 Pharmacology
Ifosfamide selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of ifosfamide-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed.
Holoxan 1000 Absorption
No information avaliable
Holoxan 1000 side effects and Toxicity
LD50 (mouse) = 390-1005 mg/kg, LD50 (rat) = 150-190 mg/kg. Side effects include nausea, vomiting and myelosuppression. Toxic effects include central nervous system toxicity (confusion, hallucinations) and urotoxic effects (cystitis, blood in urine).
Holoxan 1000 Patient Information
No information avaliable
Holoxan 1000 Organisms Affected
Humans and other mammals
