Iphosphamid
Iphosphamid Brand names, Iphosphamid Analogs
Iphosphamid Brand Names Mixture
- No information avaliable
Iphosphamid Chemical_Formula
C7H15Cl2N2O2P
Iphosphamid RX_link
http://www.rxlist.com/cgi/generic2/ifosfamide.htm
Iphosphamid fda sheet
Iphosphamid msds (material safety sheet)
Iphosphamid Synthesis Reference
No information avaliable
Iphosphamid Molecular Weight
261.085 g/mol
Iphosphamid Melting Point
39-41 oC
Iphosphamid H2O Solubility
3780 mg/L
Iphosphamid State
Solid
Iphosphamid LogP
-0.01
Iphosphamid Dosage Forms
Powder for constitution and administration by intravenous infusion
Iphosphamid Indication
For third line chemotherapy of germ cell testicular cancer. It should ordinarily be used in combination with a prophylactic agent for hemorrhagic cystitis, such as mesna.
Iphosphamid Pharmacology
Ifosfamide selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of ifosfamide-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed.
Iphosphamid Absorption
No information avaliable
Iphosphamid side effects and Toxicity
LD50 (mouse) = 390-1005 mg/kg, LD50 (rat) = 150-190 mg/kg. Side effects include nausea, vomiting and myelosuppression. Toxic effects include central nervous system toxicity (confusion, hallucinations) and urotoxic effects (cystitis, blood in urine).
Iphosphamid Patient Information
No information avaliable
Iphosphamid Organisms Affected
Humans and other mammals
