Ifosfamide
Ifosfamide Brand names, Ifosfamide Analogs
Ifosfamide Brand Names Mixture
- No information avaliable
Ifosfamide Chemical_Formula
C7H15Cl2N2O2P
Ifosfamide RX_link
http://www.rxlist.com/cgi/generic2/ifosfamide.htm
Ifosfamide fda sheet
Ifosfamide msds (material safety sheet)
Ifosfamide Synthesis Reference
No information avaliable
Ifosfamide Molecular Weight
261.085 g/mol
Ifosfamide Melting Point
39-41 oC
Ifosfamide H2O Solubility
3780 mg/L
Ifosfamide State
Solid
Ifosfamide LogP
-0.01
Ifosfamide Dosage Forms
Powder for constitution and administration by intravenous infusion
Ifosfamide Indication
For third line chemotherapy of germ cell testicular cancer. It should ordinarily be used in combination with a prophylactic agent for hemorrhagic cystitis, such as mesna.
Ifosfamide Pharmacology
Ifosfamide selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of ifosfamide-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed.
Ifosfamide Absorption
No information avaliable
Ifosfamide side effects and Toxicity
LD50 (mouse) = 390-1005 mg/kg, LD50 (rat) = 150-190 mg/kg. Side effects include nausea, vomiting and myelosuppression. Toxic effects include central nervous system toxicity (confusion, hallucinations) and urotoxic effects (cystitis, blood in urine).
Ifosfamide Patient Information
No information avaliable
Ifosfamide Organisms Affected
Humans and other mammals
