Guaiphenesin carbamate
Brand names,
Guaiphenesin carbamate
Analogs
Guaiphenesin carbamate
Brand Names Mixture
Guaiphenesin carbamate
Chemical_Formula
C14H14N2O
Guaiphenesin carbamate
RX_link
http://www.rxlist.com/cgi/generic3/metopirone.htm
Guaiphenesin carbamate
fda sheet
Guaiphenesin carbamate
msds (material safety sheet)
Guaiphenesin carbamate
Synthesis Reference
No information avaliable
Guaiphenesin carbamate
Molecular Weight
226.274 g/mol
Guaiphenesin carbamate
Melting Point
50.5 oC
Guaiphenesin carbamate
H2O Solubility
Sparingly soluble
Guaiphenesin carbamate
State
Solid
Guaiphenesin carbamate
LogP
2.303
Guaiphenesin carbamate
Dosage Forms
Capsules for oral administration (250 mg)
Guaiphenesin carbamate
Indication
Used as a diagnostic drug for testing hypothalamic-pituitary ACTH function.
Guaiphenesin carbamate
Pharmacology
Metopirone is an inhibitor of endogenous adrenal corticosteroid synthesis.
Guaiphenesin carbamate
Absorption
Absorbed rapidly and well when administered orally. Peak plasma concentrations are usually reached 1 hour after administration.
Guaiphenesin carbamate
side effects and Toxicity
Oral LD50 in rats is 521 mg/kg. One case has been recorded in which a 6-year-old girl died after two doses of Metopirone, 2 g. Symptoms of overdose include cardiac arrhythmias, hypotension, dehydration, anxiety, confusion, weakness, impairment of consciousness, nausea, vomiting, epigastric pain, and diarrhea.
Guaiphenesin carbamate
Patient Information
Guaiphenesin carbamate
Organisms Affected
Humans and other mammals