Guaiacol glyceryl ether carbamate
Brand names,
Guaiacol glyceryl ether carbamate
Analogs
Guaiacol glyceryl ether carbamate
Brand Names Mixture
Guaiacol glyceryl ether carbamate
Chemical_Formula
C14H14N2O
Guaiacol glyceryl ether carbamate
RX_link
http://www.rxlist.com/cgi/generic3/metopirone.htm
Guaiacol glyceryl ether carbamate
fda sheet
Guaiacol glyceryl ether carbamate
msds (material safety sheet)
Guaiacol glyceryl ether carbamate
Synthesis Reference
No information avaliable
Guaiacol glyceryl ether carbamate
Molecular Weight
226.274 g/mol
Guaiacol glyceryl ether carbamate
Melting Point
50.5 oC
Guaiacol glyceryl ether carbamate
H2O Solubility
Sparingly soluble
Guaiacol glyceryl ether carbamate
State
Solid
Guaiacol glyceryl ether carbamate
LogP
2.303
Guaiacol glyceryl ether carbamate
Dosage Forms
Capsules for oral administration (250 mg)
Guaiacol glyceryl ether carbamate
Indication
Used as a diagnostic drug for testing hypothalamic-pituitary ACTH function.
Guaiacol glyceryl ether carbamate
Pharmacology
Metopirone is an inhibitor of endogenous adrenal corticosteroid synthesis.
Guaiacol glyceryl ether carbamate
Absorption
Absorbed rapidly and well when administered orally. Peak plasma concentrations are usually reached 1 hour after administration.
Guaiacol glyceryl ether carbamate
side effects and Toxicity
Oral LD50 in rats is 521 mg/kg. One case has been recorded in which a 6-year-old girl died after two doses of Metopirone, 2 g. Symptoms of overdose include cardiac arrhythmias, hypotension, dehydration, anxiety, confusion, weakness, impairment of consciousness, nausea, vomiting, epigastric pain, and diarrhea.
Guaiacol glyceryl ether carbamate
Patient Information
Guaiacol glyceryl ether carbamate
Organisms Affected
Humans and other mammals