Robaxan
Brand names,
Robaxan
Analogs
Robaxan
Brand Names Mixture
Robaxan
Chemical_Formula
C14H14N2O
Robaxan
RX_link
http://www.rxlist.com/cgi/generic3/metopirone.htm
Robaxan
fda sheet
Robaxan
msds (material safety sheet)
Robaxan
Synthesis Reference
No information avaliable
Robaxan
Molecular Weight
226.274 g/mol
Robaxan
Melting Point
50.5 oC
Robaxan
H2O Solubility
Sparingly soluble
Robaxan
State
Solid
Robaxan
LogP
2.303
Robaxan
Dosage Forms
Capsules for oral administration (250 mg)
Robaxan
Indication
Used as a diagnostic drug for testing hypothalamic-pituitary ACTH function.
Robaxan
Pharmacology
Metopirone is an inhibitor of endogenous adrenal corticosteroid synthesis.
Robaxan
Absorption
Absorbed rapidly and well when administered orally. Peak plasma concentrations are usually reached 1 hour after administration.
Robaxan
side effects and Toxicity
Oral LD50 in rats is 521 mg/kg. One case has been recorded in which a 6-year-old girl died after two doses of Metopirone, 2 g. Symptoms of overdose include cardiac arrhythmias, hypotension, dehydration, anxiety, confusion, weakness, impairment of consciousness, nausea, vomiting, epigastric pain, and diarrhea.
Robaxan
Patient Information
Robaxan
Organisms Affected
Humans and other mammals