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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C14H14N2O
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RX_link
http://www.rxlist.com/cgi/generic3/metopirone.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
No information avaliable
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Molecular Weight
226.274 g/mol
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Melting Point
50.5 oC
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H2O Solubility
Sparingly soluble
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State
Solid
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LogP
2.303
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Dosage Forms
Capsules for oral administration (250 mg)
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Indication
Used as a diagnostic drug for testing hypothalamic-pituitary ACTH function.
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Pharmacology
Metopirone is an inhibitor of endogenous adrenal corticosteroid synthesis.
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Absorption
Absorbed rapidly and well when administered orally. Peak plasma concentrations are usually reached 1 hour after administration.
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side effects and Toxicity
Oral LD50 in rats is 521 mg/kg. One case has been recorded in which a 6-year-old girl died after two doses of Metopirone, 2 g. Symptoms of overdose include cardiac arrhythmias, hypotension, dehydration, anxiety, confusion, weakness, impairment of consciousness, nausea, vomiting, epigastric pain, and diarrhea.
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Patient Information
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Organisms Affected
Humans and other mammals