Glycerylguaiacolate carbamate
Brand names,
Glycerylguaiacolate carbamate
Analogs
Glycerylguaiacolate carbamate
Brand Names Mixture
Glycerylguaiacolate carbamate
Chemical_Formula
C14H14N2O
Glycerylguaiacolate carbamate
RX_link
http://www.rxlist.com/cgi/generic3/metopirone.htm
Glycerylguaiacolate carbamate
fda sheet
Glycerylguaiacolate carbamate
msds (material safety sheet)
Glycerylguaiacolate carbamate
Synthesis Reference
No information avaliable
Glycerylguaiacolate carbamate
Molecular Weight
226.274 g/mol
Glycerylguaiacolate carbamate
Melting Point
50.5 oC
Glycerylguaiacolate carbamate
H2O Solubility
Sparingly soluble
Glycerylguaiacolate carbamate
State
Solid
Glycerylguaiacolate carbamate
LogP
2.303
Glycerylguaiacolate carbamate
Dosage Forms
Capsules for oral administration (250 mg)
Glycerylguaiacolate carbamate
Indication
Used as a diagnostic drug for testing hypothalamic-pituitary ACTH function.
Glycerylguaiacolate carbamate
Pharmacology
Metopirone is an inhibitor of endogenous adrenal corticosteroid synthesis.
Glycerylguaiacolate carbamate
Absorption
Absorbed rapidly and well when administered orally. Peak plasma concentrations are usually reached 1 hour after administration.
Glycerylguaiacolate carbamate
side effects and Toxicity
Oral LD50 in rats is 521 mg/kg. One case has been recorded in which a 6-year-old girl died after two doses of Metopirone, 2 g. Symptoms of overdose include cardiac arrhythmias, hypotension, dehydration, anxiety, confusion, weakness, impairment of consciousness, nausea, vomiting, epigastric pain, and diarrhea.
Glycerylguaiacolate carbamate
Patient Information
Glycerylguaiacolate carbamate
Organisms Affected
Humans and other mammals