Relestrid
Brand names,
Relestrid
Analogs
Relestrid
Brand Names Mixture
Relestrid
Chemical_Formula
C14H14N2O
Relestrid
RX_link
http://www.rxlist.com/cgi/generic3/metopirone.htm
Relestrid
fda sheet
Relestrid
msds (material safety sheet)
Relestrid
Synthesis Reference
No information avaliable
Relestrid
Molecular Weight
226.274 g/mol
Relestrid
Melting Point
50.5 oC
Relestrid
H2O Solubility
Sparingly soluble
Relestrid
State
Solid
Relestrid
LogP
2.303
Relestrid
Dosage Forms
Capsules for oral administration (250 mg)
Relestrid
Indication
Used as a diagnostic drug for testing hypothalamic-pituitary ACTH function.
Relestrid
Pharmacology
Metopirone is an inhibitor of endogenous adrenal corticosteroid synthesis.
Relestrid
Absorption
Absorbed rapidly and well when administered orally. Peak plasma concentrations are usually reached 1 hour after administration.
Relestrid
side effects and Toxicity
Oral LD50 in rats is 521 mg/kg. One case has been recorded in which a 6-year-old girl died after two doses of Metopirone, 2 g. Symptoms of overdose include cardiac arrhythmias, hypotension, dehydration, anxiety, confusion, weakness, impairment of consciousness, nausea, vomiting, epigastric pain, and diarrhea.
Relestrid
Patient Information
Relestrid
Organisms Affected
Humans and other mammals