Glycerylguajacol-Carbamat
Brand names,
Glycerylguajacol-Carbamat
Analogs
Glycerylguajacol-Carbamat
Brand Names Mixture
Glycerylguajacol-Carbamat
Chemical_Formula
C14H14N2O
Glycerylguajacol-Carbamat
RX_link
http://www.rxlist.com/cgi/generic3/metopirone.htm
Glycerylguajacol-Carbamat
fda sheet
Glycerylguajacol-Carbamat
msds (material safety sheet)
Glycerylguajacol-Carbamat
Synthesis Reference
No information avaliable
Glycerylguajacol-Carbamat
Molecular Weight
226.274 g/mol
Glycerylguajacol-Carbamat
Melting Point
50.5 oC
Glycerylguajacol-Carbamat
H2O Solubility
Sparingly soluble
Glycerylguajacol-Carbamat
State
Solid
Glycerylguajacol-Carbamat
LogP
2.303
Glycerylguajacol-Carbamat
Dosage Forms
Capsules for oral administration (250 mg)
Glycerylguajacol-Carbamat
Indication
Used as a diagnostic drug for testing hypothalamic-pituitary ACTH function.
Glycerylguajacol-Carbamat
Pharmacology
Metopirone is an inhibitor of endogenous adrenal corticosteroid synthesis.
Glycerylguajacol-Carbamat
Absorption
Absorbed rapidly and well when administered orally. Peak plasma concentrations are usually reached 1 hour after administration.
Glycerylguajacol-Carbamat
side effects and Toxicity
Oral LD50 in rats is 521 mg/kg. One case has been recorded in which a 6-year-old girl died after two doses of Metopirone, 2 g. Symptoms of overdose include cardiac arrhythmias, hypotension, dehydration, anxiety, confusion, weakness, impairment of consciousness, nausea, vomiting, epigastric pain, and diarrhea.
Glycerylguajacol-Carbamat
Patient Information
Glycerylguajacol-Carbamat
Organisms Affected
Humans and other mammals