Robaxon
Brand names,
Robaxon
Analogs
Robaxon
Brand Names Mixture
Robaxon
Chemical_Formula
C14H14N2O
Robaxon
RX_link
http://www.rxlist.com/cgi/generic3/metopirone.htm
Robaxon
fda sheet
Robaxon
msds (material safety sheet)
Robaxon
Synthesis Reference
No information avaliable
Robaxon
Molecular Weight
226.274 g/mol
Robaxon
Melting Point
50.5 oC
Robaxon
H2O Solubility
Sparingly soluble
Robaxon
State
Solid
Robaxon
LogP
2.303
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Dosage Forms
Capsules for oral administration (250 mg)
Robaxon
Indication
Used as a diagnostic drug for testing hypothalamic-pituitary ACTH function.
Robaxon
Pharmacology
Metopirone is an inhibitor of endogenous adrenal corticosteroid synthesis.
Robaxon
Absorption
Absorbed rapidly and well when administered orally. Peak plasma concentrations are usually reached 1 hour after administration.
Robaxon
side effects and Toxicity
Oral LD50 in rats is 521 mg/kg. One case has been recorded in which a 6-year-old girl died after two doses of Metopirone, 2 g. Symptoms of overdose include cardiac arrhythmias, hypotension, dehydration, anxiety, confusion, weakness, impairment of consciousness, nausea, vomiting, epigastric pain, and diarrhea.
Robaxon
Patient Information
Robaxon
Organisms Affected
Humans and other mammals