Methocal
Brand names,
Methocal
Analogs
Methocal
Brand Names Mixture
Methocal
Chemical_Formula
C14H14N2O
Methocal
RX_link
http://www.rxlist.com/cgi/generic3/metopirone.htm
Methocal
fda sheet
Methocal
msds (material safety sheet)
Methocal
Synthesis Reference
No information avaliable
Methocal
Molecular Weight
226.274 g/mol
Methocal
Melting Point
50.5 oC
Methocal
H2O Solubility
Sparingly soluble
Methocal
State
Solid
Methocal
LogP
2.303
Methocal
Dosage Forms
Capsules for oral administration (250 mg)
Methocal
Indication
Used as a diagnostic drug for testing hypothalamic-pituitary ACTH function.
Methocal
Pharmacology
Metopirone is an inhibitor of endogenous adrenal corticosteroid synthesis.
Methocal
Absorption
Absorbed rapidly and well when administered orally. Peak plasma concentrations are usually reached 1 hour after administration.
Methocal
side effects and Toxicity
Oral LD50 in rats is 521 mg/kg. One case has been recorded in which a 6-year-old girl died after two doses of Metopirone, 2 g. Symptoms of overdose include cardiac arrhythmias, hypotension, dehydration, anxiety, confusion, weakness, impairment of consciousness, nausea, vomiting, epigastric pain, and diarrhea.
Methocal
Patient Information
Methocal
Organisms Affected
Humans and other mammals