Guaiphenesine carbamate
Brand names,
Guaiphenesine carbamate
Analogs
Guaiphenesine carbamate
Brand Names Mixture
Guaiphenesine carbamate
Chemical_Formula
C14H14N2O
Guaiphenesine carbamate
RX_link
http://www.rxlist.com/cgi/generic3/metopirone.htm
Guaiphenesine carbamate
fda sheet
Guaiphenesine carbamate
msds (material safety sheet)
Guaiphenesine carbamate
Synthesis Reference
No information avaliable
Guaiphenesine carbamate
Molecular Weight
226.274 g/mol
Guaiphenesine carbamate
Melting Point
50.5 oC
Guaiphenesine carbamate
H2O Solubility
Sparingly soluble
Guaiphenesine carbamate
State
Solid
Guaiphenesine carbamate
LogP
2.303
Guaiphenesine carbamate
Dosage Forms
Capsules for oral administration (250 mg)
Guaiphenesine carbamate
Indication
Used as a diagnostic drug for testing hypothalamic-pituitary ACTH function.
Guaiphenesine carbamate
Pharmacology
Metopirone is an inhibitor of endogenous adrenal corticosteroid synthesis.
Guaiphenesine carbamate
Absorption
Absorbed rapidly and well when administered orally. Peak plasma concentrations are usually reached 1 hour after administration.
Guaiphenesine carbamate
side effects and Toxicity
Oral LD50 in rats is 521 mg/kg. One case has been recorded in which a 6-year-old girl died after two doses of Metopirone, 2 g. Symptoms of overdose include cardiac arrhythmias, hypotension, dehydration, anxiety, confusion, weakness, impairment of consciousness, nausea, vomiting, epigastric pain, and diarrhea.
Guaiphenesine carbamate
Patient Information
Guaiphenesine carbamate
Organisms Affected
Humans and other mammals