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Daunorubicin Brand names, Daunorubicin Analogs

Daunorubicin Brand Names Mixture

  • No information avaliable

Daunorubicin Chemical_Formula


Daunorubicin RX_link


Daunorubicin fda sheet


Daunorubicin msds (material safety sheet)

Daunorubicin MSDS

Daunorubicin Synthesis Reference

J. P. Parsh et al. J. Pharm. Sci. 56, 1691 (1967);

Daunorubicin Molecular Weight

527.52 g/mol

Daunorubicin Melting Point

208-209 oC

Daunorubicin H2O Solubility

39.2 mg/L

Daunorubicin State


Daunorubicin LogP


Daunorubicin Dosage Forms

Powder for solution; Suspension

Daunorubicin Indication

For remission induction in acute nonlymphocytic leukemia (myelogenous, monocytic, erythroid) of adults and for remission induction in acute lymphocytic leukemia of children and adults.

Daunorubicin Pharmacology

Daunorubicin is an antineoplastic in the anthracycline class. General properties of drugs in this class include: interaction with DNA in a variety of different ways including intercalation (squeezing between the base pairs), DNA strand breakage and inhibition with the enzyme topoisomerase II. Most of these compounds have been isolated from natural sources and antibiotics. However, they lack the specificity of the antimicrobial antibiotics and thus produce significant toxicity. The anthracyclines are among the most important antitumor drugs available. Doxorubicin is widely used for the treatment of several solid tumors while daunorubicin and idarubicin are used exclusively for the treatment of leukemia. Daunorubicin may also inhibit polymerase activity, affect regulation of gene expression, and produce free radical damage to DNA. Daunorubicin possesses an antitumor effect against a wide spectrum of tumors, either grafted or spontaneous. The anthracyclines are cell cycle-nonspecific.

Daunorubicin Absorption

No information avaliable

Daunorubicin side effects and Toxicity

LD50=20 mg/kg (mice, IV); LD50=13 mg/kg (rat, IV)

Daunorubicin Patient Information

Daunorubicin Organisms Affected

Humans and other mammals