Rubidomycin Hydrochloride

• Antibiotics
• Antineoplastic Agents
• ATC:L01DB02

• Acetyladriamycin
• Anthracyline
• Antibiotics From Streptomyces Coeruleorubidus
• Cerubidin
• Cerubidine
• DM1
• Daunamycin
• Daunarubicinum
• Daunoblastin
• Daunomycin
• Daunomycin Hydrochloride
• Daunomycin, Hydrochloride
• Daunorrubicina
• Daunorubicin Hcl
• Daunorubicin Hydrochloride
• Daunorubicin, Hydrochloride
• Daunorubicine
• Daunorubicinum [Inn-Latin]
• Daunoxome
• Leukaemomycin C
• Ondena
• Rcra Waste No. U059
• Rp 13057 Hydrochloride
• Rubidomycin
• Rubidomycin Hydrochloride
• Rubomycin C

• No information avaliable

C₂₇H₂₉NO₁₀

http://www.rxlist.com/cgi/generic2/daunorubicin.htm

http://www.accessdata.fda.gov/scripts/cder/onctools/labels.cfm?GN=daunorubicin,%20daunomycin

Rubidomycin_Hydrochloride MSDS

J. P. Parsh et al. J. Pharm. Sci. 56, 1691 (1967);

527.52 g/mol

208-209 ^oC

39.2 mg/L

Solid

0.766

Powder for solution; Suspension

For remission induction in acute nonlymphocytic leukemia (myelogenous, monocytic, erythroid) of adults and for remission induction in acute lymphocytic leukemia of children and adults.

Daunorubicin is an antineoplastic in the anthracycline class. General properties of drugs in this class include: interaction with DNA in a variety of different ways including intercalation (squeezing between the base pairs), DNA strand breakage and inhibition with the enzyme topoisomerase II. Most of these compounds have been isolated from natural sources and antibiotics. However, they lack the specificity of the antimicrobial antibiotics and thus produce significant toxicity. The anthracyclines are among the most important antitumor drugs available. Doxorubicin is widely used for the treatment of several solid tumors while daunorubicin and idarubicin are used exclusively for the treatment of leukemia. Daunorubicin may also inhibit polymerase activity, affect regulation of gene expression, and produce free radical damage to DNA. Daunorubicin possesses an antitumor effect against a wide spectrum of tumors, either grafted or spontaneous. The anthracyclines are cell cycle-nonspecific.

No information avaliable

LD₅₀=20 mg/kg (mice, IV); LD₅₀=13 mg/kg (rat, IV)

Humans and other mammals