Antibiotics From Streptomyces Coeruleorubidus en es it fr

Antibiotics From Streptomyces Coeruleorubidus Brand names, Antibiotics From Streptomyces Coeruleorubidus Analogs

Antibiotics From Streptomyces Coeruleorubidus Brand Names Mixture

  • No information avaliable

Antibiotics From Streptomyces Coeruleorubidus Chemical_Formula

C27H29NO10

Antibiotics From Streptomyces Coeruleorubidus RX_link

http://www.rxlist.com/cgi/generic2/daunorubicin.htm

Antibiotics From Streptomyces Coeruleorubidus fda sheet

http://www.accessdata.fda.gov/scripts/cder/onctools/labels.cfm?GN=daunorubicin,%20daunomycin

Antibiotics From Streptomyces Coeruleorubidus msds (material safety sheet)

Antibiotics_From_Streptomyces_Coeruleorubidus MSDS

Antibiotics From Streptomyces Coeruleorubidus Synthesis Reference

J. P. Parsh et al. J. Pharm. Sci. 56, 1691 (1967);

Antibiotics From Streptomyces Coeruleorubidus Molecular Weight

527.52 g/mol

Antibiotics From Streptomyces Coeruleorubidus Melting Point

208-209 oC

Antibiotics From Streptomyces Coeruleorubidus H2O Solubility

39.2 mg/L

Antibiotics From Streptomyces Coeruleorubidus State

Solid

Antibiotics From Streptomyces Coeruleorubidus LogP

0.766

Antibiotics From Streptomyces Coeruleorubidus Dosage Forms

Powder for solution; Suspension

Antibiotics From Streptomyces Coeruleorubidus Indication

For remission induction in acute nonlymphocytic leukemia (myelogenous, monocytic, erythroid) of adults and for remission induction in acute lymphocytic leukemia of children and adults.

Antibiotics From Streptomyces Coeruleorubidus Pharmacology

Daunorubicin is an antineoplastic in the anthracycline class. General properties of drugs in this class include: interaction with DNA in a variety of different ways including intercalation (squeezing between the base pairs), DNA strand breakage and inhibition with the enzyme topoisomerase II. Most of these compounds have been isolated from natural sources and antibiotics. However, they lack the specificity of the antimicrobial antibiotics and thus produce significant toxicity. The anthracyclines are among the most important antitumor drugs available. Doxorubicin is widely used for the treatment of several solid tumors while daunorubicin and idarubicin are used exclusively for the treatment of leukemia. Daunorubicin may also inhibit polymerase activity, affect regulation of gene expression, and produce free radical damage to DNA. Daunorubicin possesses an antitumor effect against a wide spectrum of tumors, either grafted or spontaneous. The anthracyclines are cell cycle-nonspecific.

Antibiotics From Streptomyces Coeruleorubidus Absorption

No information avaliable

Antibiotics From Streptomyces Coeruleorubidus side effects and Toxicity

LD50=20 mg/kg (mice, IV); LD50=13 mg/kg (rat, IV)

Antibiotics From Streptomyces Coeruleorubidus Patient Information

Antibiotics From Streptomyces Coeruleorubidus Organisms Affected

Humans and other mammals