Antibiotics From Streptomyces Coeruleorubidus
Antibiotics From Streptomyces Coeruleorubidus Brand names, Antibiotics From Streptomyces Coeruleorubidus Analogs
- Acetyladriamycin
- Anthracyline
- Antibiotics From Streptomyces Coeruleorubidus
- Cerubidin
- Cerubidine
- DM1
- Daunamycin
- Daunarubicinum
- Daunoblastin
- Daunomycin
- Daunomycin Hydrochloride
- Daunomycin, Hydrochloride
- Daunorrubicina
- Daunorubicin Hcl
- Daunorubicin Hydrochloride
- Daunorubicin, Hydrochloride
- Daunorubicine
- Daunorubicinum [Inn-Latin]
- Daunoxome
- Leukaemomycin C
- Ondena
- Rcra Waste No. U059
- Rp 13057 Hydrochloride
- Rubidomycin
- Rubidomycin Hydrochloride
- Rubomycin C
Antibiotics From Streptomyces Coeruleorubidus Brand Names Mixture
- No information avaliable
Antibiotics From Streptomyces Coeruleorubidus Chemical_Formula
C27H29NO10
Antibiotics From Streptomyces Coeruleorubidus RX_link
http://www.rxlist.com/cgi/generic2/daunorubicin.htm
Antibiotics From Streptomyces Coeruleorubidus fda sheet
Antibiotics From Streptomyces Coeruleorubidus msds (material safety sheet)
Antibiotics From Streptomyces Coeruleorubidus Synthesis Reference
J. P. Parsh et al. J. Pharm. Sci. 56, 1691 (1967);
Antibiotics From Streptomyces Coeruleorubidus Molecular Weight
527.52 g/mol
Antibiotics From Streptomyces Coeruleorubidus Melting Point
208-209 oC
Antibiotics From Streptomyces Coeruleorubidus H2O Solubility
39.2 mg/L
Antibiotics From Streptomyces Coeruleorubidus State
Solid
Antibiotics From Streptomyces Coeruleorubidus LogP
0.766
Antibiotics From Streptomyces Coeruleorubidus Dosage Forms
Powder for solution; Suspension
Antibiotics From Streptomyces Coeruleorubidus Indication
For remission induction in acute nonlymphocytic leukemia (myelogenous, monocytic, erythroid) of adults and for remission induction in acute lymphocytic leukemia of children and adults.
Antibiotics From Streptomyces Coeruleorubidus Pharmacology
Daunorubicin is an antineoplastic in the anthracycline class. General properties of drugs in this class include: interaction with DNA in a variety of different ways including intercalation (squeezing between the base pairs), DNA strand breakage and inhibition with the enzyme topoisomerase II. Most of these compounds have been isolated from natural sources and antibiotics. However, they lack the specificity of the antimicrobial antibiotics and thus produce significant toxicity. The anthracyclines are among the most important antitumor drugs available. Doxorubicin is widely used for the treatment of several solid tumors while daunorubicin and idarubicin are used exclusively for the treatment of leukemia. Daunorubicin may also inhibit polymerase activity, affect regulation of gene expression, and produce free radical damage to DNA. Daunorubicin possesses an antitumor effect against a wide spectrum of tumors, either grafted or spontaneous. The anthracyclines are cell cycle-nonspecific.
Antibiotics From Streptomyces Coeruleorubidus Absorption
No information avaliable
Antibiotics From Streptomyces Coeruleorubidus side effects and Toxicity
LD50=20 mg/kg (mice, IV); LD50=13 mg/kg (rat, IV)
Antibiotics From Streptomyces Coeruleorubidus Patient Information
Antibiotics From Streptomyces Coeruleorubidus Organisms Affected
Humans and other mammals
