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Daunomycin Brand names, Daunomycin Analogs

Daunomycin Brand Names Mixture

  • No information avaliable

Daunomycin Chemical_Formula


Daunomycin RX_link


Daunomycin fda sheet


Daunomycin msds (material safety sheet)

Daunomycin MSDS

Daunomycin Synthesis Reference

J. P. Parsh et al. J. Pharm. Sci. 56, 1691 (1967);

Daunomycin Molecular Weight

527.52 g/mol

Daunomycin Melting Point

208-209 oC

Daunomycin H2O Solubility

39.2 mg/L

Daunomycin State


Daunomycin LogP


Daunomycin Dosage Forms

Powder for solution; Suspension

Daunomycin Indication

For remission induction in acute nonlymphocytic leukemia (myelogenous, monocytic, erythroid) of adults and for remission induction in acute lymphocytic leukemia of children and adults.

Daunomycin Pharmacology

Daunorubicin is an antineoplastic in the anthracycline class. General properties of drugs in this class include: interaction with DNA in a variety of different ways including intercalation (squeezing between the base pairs), DNA strand breakage and inhibition with the enzyme topoisomerase II. Most of these compounds have been isolated from natural sources and antibiotics. However, they lack the specificity of the antimicrobial antibiotics and thus produce significant toxicity. The anthracyclines are among the most important antitumor drugs available. Doxorubicin is widely used for the treatment of several solid tumors while daunorubicin and idarubicin are used exclusively for the treatment of leukemia. Daunorubicin may also inhibit polymerase activity, affect regulation of gene expression, and produce free radical damage to DNA. Daunorubicin possesses an antitumor effect against a wide spectrum of tumors, either grafted or spontaneous. The anthracyclines are cell cycle-nonspecific.

Daunomycin Absorption

No information avaliable

Daunomycin side effects and Toxicity

LD50=20 mg/kg (mice, IV); LD50=13 mg/kg (rat, IV)

Daunomycin Patient Information

Daunomycin Organisms Affected

Humans and other mammals