Daunorubicin, Hydrochloride en es it fr

Daunorubicin, Hydrochloride Brand names, Daunorubicin, Hydrochloride Analogs

Daunorubicin, Hydrochloride Brand Names Mixture

  • No information avaliable

Daunorubicin, Hydrochloride Chemical_Formula

C27H29NO10

Daunorubicin, Hydrochloride RX_link

http://www.rxlist.com/cgi/generic2/daunorubicin.htm

Daunorubicin, Hydrochloride fda sheet

http://www.accessdata.fda.gov/scripts/cder/onctools/labels.cfm?GN=daunorubicin,%20daunomycin

Daunorubicin, Hydrochloride msds (material safety sheet)

Daunorubicin,_Hydrochloride MSDS

Daunorubicin, Hydrochloride Synthesis Reference

J. P. Parsh et al. J. Pharm. Sci. 56, 1691 (1967);

Daunorubicin, Hydrochloride Molecular Weight

527.52 g/mol

Daunorubicin, Hydrochloride Melting Point

208-209 oC

Daunorubicin, Hydrochloride H2O Solubility

39.2 mg/L

Daunorubicin, Hydrochloride State

Solid

Daunorubicin, Hydrochloride LogP

0.766

Daunorubicin, Hydrochloride Dosage Forms

Powder for solution; Suspension

Daunorubicin, Hydrochloride Indication

For remission induction in acute nonlymphocytic leukemia (myelogenous, monocytic, erythroid) of adults and for remission induction in acute lymphocytic leukemia of children and adults.

Daunorubicin, Hydrochloride Pharmacology

Daunorubicin is an antineoplastic in the anthracycline class. General properties of drugs in this class include: interaction with DNA in a variety of different ways including intercalation (squeezing between the base pairs), DNA strand breakage and inhibition with the enzyme topoisomerase II. Most of these compounds have been isolated from natural sources and antibiotics. However, they lack the specificity of the antimicrobial antibiotics and thus produce significant toxicity. The anthracyclines are among the most important antitumor drugs available. Doxorubicin is widely used for the treatment of several solid tumors while daunorubicin and idarubicin are used exclusively for the treatment of leukemia. Daunorubicin may also inhibit polymerase activity, affect regulation of gene expression, and produce free radical damage to DNA. Daunorubicin possesses an antitumor effect against a wide spectrum of tumors, either grafted or spontaneous. The anthracyclines are cell cycle-nonspecific.

Daunorubicin, Hydrochloride Absorption

No information avaliable

Daunorubicin, Hydrochloride side effects and Toxicity

LD50=20 mg/kg (mice, IV); LD50=13 mg/kg (rat, IV)

Daunorubicin, Hydrochloride Patient Information

Daunorubicin, Hydrochloride Organisms Affected

Humans and other mammals