Daunomycin, Hydrochloride en es it fr

Daunomycin, Hydrochloride Brand names, Daunomycin, Hydrochloride Analogs

Daunomycin, Hydrochloride Brand Names Mixture

  • No information avaliable

Daunomycin, Hydrochloride Chemical_Formula

C27H29NO10

Daunomycin, Hydrochloride RX_link

http://www.rxlist.com/cgi/generic2/daunorubicin.htm

Daunomycin, Hydrochloride fda sheet

http://www.accessdata.fda.gov/scripts/cder/onctools/labels.cfm?GN=daunorubicin,%20daunomycin

Daunomycin, Hydrochloride msds (material safety sheet)

Daunomycin,_Hydrochloride MSDS

Daunomycin, Hydrochloride Synthesis Reference

J. P. Parsh et al. J. Pharm. Sci. 56, 1691 (1967);

Daunomycin, Hydrochloride Molecular Weight

527.52 g/mol

Daunomycin, Hydrochloride Melting Point

208-209 oC

Daunomycin, Hydrochloride H2O Solubility

39.2 mg/L

Daunomycin, Hydrochloride State

Solid

Daunomycin, Hydrochloride LogP

0.766

Daunomycin, Hydrochloride Dosage Forms

Powder for solution; Suspension

Daunomycin, Hydrochloride Indication

For remission induction in acute nonlymphocytic leukemia (myelogenous, monocytic, erythroid) of adults and for remission induction in acute lymphocytic leukemia of children and adults.

Daunomycin, Hydrochloride Pharmacology

Daunorubicin is an antineoplastic in the anthracycline class. General properties of drugs in this class include: interaction with DNA in a variety of different ways including intercalation (squeezing between the base pairs), DNA strand breakage and inhibition with the enzyme topoisomerase II. Most of these compounds have been isolated from natural sources and antibiotics. However, they lack the specificity of the antimicrobial antibiotics and thus produce significant toxicity. The anthracyclines are among the most important antitumor drugs available. Doxorubicin is widely used for the treatment of several solid tumors while daunorubicin and idarubicin are used exclusively for the treatment of leukemia. Daunorubicin may also inhibit polymerase activity, affect regulation of gene expression, and produce free radical damage to DNA. Daunorubicin possesses an antitumor effect against a wide spectrum of tumors, either grafted or spontaneous. The anthracyclines are cell cycle-nonspecific.

Daunomycin, Hydrochloride Absorption

No information avaliable

Daunomycin, Hydrochloride side effects and Toxicity

LD50=20 mg/kg (mice, IV); LD50=13 mg/kg (rat, IV)

Daunomycin, Hydrochloride Patient Information

Daunomycin, Hydrochloride Organisms Affected

Humans and other mammals