Daunomycin, Hydrochloride
Daunomycin, Hydrochloride Brand names, Daunomycin, Hydrochloride Analogs
- Acetyladriamycin
- Anthracyline
- Antibiotics From Streptomyces Coeruleorubidus
- Cerubidin
- Cerubidine
- DM1
- Daunamycin
- Daunarubicinum
- Daunoblastin
- Daunomycin
- Daunomycin Hydrochloride
- Daunomycin, Hydrochloride
- Daunorrubicina
- Daunorubicin Hcl
- Daunorubicin Hydrochloride
- Daunorubicin, Hydrochloride
- Daunorubicine
- Daunorubicinum [Inn-Latin]
- Daunoxome
- Leukaemomycin C
- Ondena
- Rcra Waste No. U059
- Rp 13057 Hydrochloride
- Rubidomycin
- Rubidomycin Hydrochloride
- Rubomycin C
Daunomycin, Hydrochloride Brand Names Mixture
- No information avaliable
Daunomycin, Hydrochloride Chemical_Formula
C27H29NO10
Daunomycin, Hydrochloride RX_link
http://www.rxlist.com/cgi/generic2/daunorubicin.htm
Daunomycin, Hydrochloride fda sheet
Daunomycin, Hydrochloride msds (material safety sheet)
Daunomycin, Hydrochloride Synthesis Reference
J. P. Parsh et al. J. Pharm. Sci. 56, 1691 (1967);
Daunomycin, Hydrochloride Molecular Weight
527.52 g/mol
Daunomycin, Hydrochloride Melting Point
208-209 oC
Daunomycin, Hydrochloride H2O Solubility
39.2 mg/L
Daunomycin, Hydrochloride State
Solid
Daunomycin, Hydrochloride LogP
0.766
Daunomycin, Hydrochloride Dosage Forms
Powder for solution; Suspension
Daunomycin, Hydrochloride Indication
For remission induction in acute nonlymphocytic leukemia (myelogenous, monocytic, erythroid) of adults and for remission induction in acute lymphocytic leukemia of children and adults.
Daunomycin, Hydrochloride Pharmacology
Daunorubicin is an antineoplastic in the anthracycline class. General properties of drugs in this class include: interaction with DNA in a variety of different ways including intercalation (squeezing between the base pairs), DNA strand breakage and inhibition with the enzyme topoisomerase II. Most of these compounds have been isolated from natural sources and antibiotics. However, they lack the specificity of the antimicrobial antibiotics and thus produce significant toxicity. The anthracyclines are among the most important antitumor drugs available. Doxorubicin is widely used for the treatment of several solid tumors while daunorubicin and idarubicin are used exclusively for the treatment of leukemia. Daunorubicin may also inhibit polymerase activity, affect regulation of gene expression, and produce free radical damage to DNA. Daunorubicin possesses an antitumor effect against a wide spectrum of tumors, either grafted or spontaneous. The anthracyclines are cell cycle-nonspecific.
Daunomycin, Hydrochloride Absorption
No information avaliable
Daunomycin, Hydrochloride side effects and Toxicity
LD50=20 mg/kg (mice, IV); LD50=13 mg/kg (rat, IV)
Daunomycin, Hydrochloride Patient Information
Daunomycin, Hydrochloride Organisms Affected
Humans and other mammals
