Rcra Waste No. U059 en es it fr

Rcra Waste No. U059 Brand names, Rcra Waste No. U059 Analogs

Rcra Waste No. U059 Brand Names Mixture

  • No information avaliable

Rcra Waste No. U059 Chemical_Formula

C27H29NO10

Rcra Waste No. U059 RX_link

http://www.rxlist.com/cgi/generic2/daunorubicin.htm

Rcra Waste No. U059 fda sheet

http://www.accessdata.fda.gov/scripts/cder/onctools/labels.cfm?GN=daunorubicin,%20daunomycin

Rcra Waste No. U059 msds (material safety sheet)

Rcra_Waste_No._U059 MSDS

Rcra Waste No. U059 Synthesis Reference

J. P. Parsh et al. J. Pharm. Sci. 56, 1691 (1967);

Rcra Waste No. U059 Molecular Weight

527.52 g/mol

Rcra Waste No. U059 Melting Point

208-209 oC

Rcra Waste No. U059 H2O Solubility

39.2 mg/L

Rcra Waste No. U059 State

Solid

Rcra Waste No. U059 LogP

0.766

Rcra Waste No. U059 Dosage Forms

Powder for solution; Suspension

Rcra Waste No. U059 Indication

For remission induction in acute nonlymphocytic leukemia (myelogenous, monocytic, erythroid) of adults and for remission induction in acute lymphocytic leukemia of children and adults.

Rcra Waste No. U059 Pharmacology

Daunorubicin is an antineoplastic in the anthracycline class. General properties of drugs in this class include: interaction with DNA in a variety of different ways including intercalation (squeezing between the base pairs), DNA strand breakage and inhibition with the enzyme topoisomerase II. Most of these compounds have been isolated from natural sources and antibiotics. However, they lack the specificity of the antimicrobial antibiotics and thus produce significant toxicity. The anthracyclines are among the most important antitumor drugs available. Doxorubicin is widely used for the treatment of several solid tumors while daunorubicin and idarubicin are used exclusively for the treatment of leukemia. Daunorubicin may also inhibit polymerase activity, affect regulation of gene expression, and produce free radical damage to DNA. Daunorubicin possesses an antitumor effect against a wide spectrum of tumors, either grafted or spontaneous. The anthracyclines are cell cycle-nonspecific.

Rcra Waste No. U059 Absorption

No information avaliable

Rcra Waste No. U059 side effects and Toxicity

LD50=20 mg/kg (mice, IV); LD50=13 mg/kg (rat, IV)

Rcra Waste No. U059 Patient Information

Rcra Waste No. U059 Organisms Affected

Humans and other mammals