Rubidomycin en es it fr

Rubidomycin Brand names, Rubidomycin Analogs

Rubidomycin Brand Names Mixture

  • No information avaliable

Rubidomycin Chemical_Formula


Rubidomycin RX_link

Rubidomycin fda sheet,%20daunomycin

Rubidomycin msds (material safety sheet)

Rubidomycin MSDS

Rubidomycin Synthesis Reference

J. P. Parsh et al. J. Pharm. Sci. 56, 1691 (1967);

Rubidomycin Molecular Weight

527.52 g/mol

Rubidomycin Melting Point

208-209 oC

Rubidomycin H2O Solubility

39.2 mg/L

Rubidomycin State


Rubidomycin LogP


Rubidomycin Dosage Forms

Powder for solution; Suspension

Rubidomycin Indication

For remission induction in acute nonlymphocytic leukemia (myelogenous, monocytic, erythroid) of adults and for remission induction in acute lymphocytic leukemia of children and adults.

Rubidomycin Pharmacology

Daunorubicin is an antineoplastic in the anthracycline class. General properties of drugs in this class include: interaction with DNA in a variety of different ways including intercalation (squeezing between the base pairs), DNA strand breakage and inhibition with the enzyme topoisomerase II. Most of these compounds have been isolated from natural sources and antibiotics. However, they lack the specificity of the antimicrobial antibiotics and thus produce significant toxicity. The anthracyclines are among the most important antitumor drugs available. Doxorubicin is widely used for the treatment of several solid tumors while daunorubicin and idarubicin are used exclusively for the treatment of leukemia. Daunorubicin may also inhibit polymerase activity, affect regulation of gene expression, and produce free radical damage to DNA. Daunorubicin possesses an antitumor effect against a wide spectrum of tumors, either grafted or spontaneous. The anthracyclines are cell cycle-nonspecific.

Rubidomycin Absorption

No information avaliable

Rubidomycin side effects and Toxicity

LD50=20 mg/kg (mice, IV); LD50=13 mg/kg (rat, IV)

Rubidomycin Patient Information

Rubidomycin Organisms Affected

Humans and other mammals