Rp 13057 Hydrochloride en es it fr

Rp 13057 Hydrochloride Brand names, Rp 13057 Hydrochloride Analogs

Rp 13057 Hydrochloride Brand Names Mixture

  • No information avaliable

Rp 13057 Hydrochloride Chemical_Formula

C27H29NO10

Rp 13057 Hydrochloride RX_link

http://www.rxlist.com/cgi/generic2/daunorubicin.htm

Rp 13057 Hydrochloride fda sheet

http://www.accessdata.fda.gov/scripts/cder/onctools/labels.cfm?GN=daunorubicin,%20daunomycin

Rp 13057 Hydrochloride msds (material safety sheet)

Rp_13057_Hydrochloride MSDS

Rp 13057 Hydrochloride Synthesis Reference

J. P. Parsh et al. J. Pharm. Sci. 56, 1691 (1967);

Rp 13057 Hydrochloride Molecular Weight

527.52 g/mol

Rp 13057 Hydrochloride Melting Point

208-209 oC

Rp 13057 Hydrochloride H2O Solubility

39.2 mg/L

Rp 13057 Hydrochloride State

Solid

Rp 13057 Hydrochloride LogP

0.766

Rp 13057 Hydrochloride Dosage Forms

Powder for solution; Suspension

Rp 13057 Hydrochloride Indication

For remission induction in acute nonlymphocytic leukemia (myelogenous, monocytic, erythroid) of adults and for remission induction in acute lymphocytic leukemia of children and adults.

Rp 13057 Hydrochloride Pharmacology

Daunorubicin is an antineoplastic in the anthracycline class. General properties of drugs in this class include: interaction with DNA in a variety of different ways including intercalation (squeezing between the base pairs), DNA strand breakage and inhibition with the enzyme topoisomerase II. Most of these compounds have been isolated from natural sources and antibiotics. However, they lack the specificity of the antimicrobial antibiotics and thus produce significant toxicity. The anthracyclines are among the most important antitumor drugs available. Doxorubicin is widely used for the treatment of several solid tumors while daunorubicin and idarubicin are used exclusively for the treatment of leukemia. Daunorubicin may also inhibit polymerase activity, affect regulation of gene expression, and produce free radical damage to DNA. Daunorubicin possesses an antitumor effect against a wide spectrum of tumors, either grafted or spontaneous. The anthracyclines are cell cycle-nonspecific.

Rp 13057 Hydrochloride Absorption

No information avaliable

Rp 13057 Hydrochloride side effects and Toxicity

LD50=20 mg/kg (mice, IV); LD50=13 mg/kg (rat, IV)

Rp 13057 Hydrochloride Patient Information

Rp 13057 Hydrochloride Organisms Affected

Humans and other mammals