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Anthracyline Brand names, Anthracyline Analogs

Anthracyline Brand Names Mixture

  • No information avaliable

Anthracyline Chemical_Formula

C27H29NO10

Anthracyline RX_link

http://www.rxlist.com/cgi/generic2/daunorubicin.htm

Anthracyline fda sheet

http://www.accessdata.fda.gov/scripts/cder/onctools/labels.cfm?GN=daunorubicin,%20daunomycin

Anthracyline msds (material safety sheet)

Anthracyline MSDS

Anthracyline Synthesis Reference

J. P. Parsh et al. J. Pharm. Sci. 56, 1691 (1967);

Anthracyline Molecular Weight

527.52 g/mol

Anthracyline Melting Point

208-209 oC

Anthracyline H2O Solubility

39.2 mg/L

Anthracyline State

Solid

Anthracyline LogP

0.766

Anthracyline Dosage Forms

Powder for solution; Suspension

Anthracyline Indication

For remission induction in acute nonlymphocytic leukemia (myelogenous, monocytic, erythroid) of adults and for remission induction in acute lymphocytic leukemia of children and adults.

Anthracyline Pharmacology

Daunorubicin is an antineoplastic in the anthracycline class. General properties of drugs in this class include: interaction with DNA in a variety of different ways including intercalation (squeezing between the base pairs), DNA strand breakage and inhibition with the enzyme topoisomerase II. Most of these compounds have been isolated from natural sources and antibiotics. However, they lack the specificity of the antimicrobial antibiotics and thus produce significant toxicity. The anthracyclines are among the most important antitumor drugs available. Doxorubicin is widely used for the treatment of several solid tumors while daunorubicin and idarubicin are used exclusively for the treatment of leukemia. Daunorubicin may also inhibit polymerase activity, affect regulation of gene expression, and produce free radical damage to DNA. Daunorubicin possesses an antitumor effect against a wide spectrum of tumors, either grafted or spontaneous. The anthracyclines are cell cycle-nonspecific.

Anthracyline Absorption

No information avaliable

Anthracyline side effects and Toxicity

LD50=20 mg/kg (mice, IV); LD50=13 mg/kg (rat, IV)

Anthracyline Patient Information

Anthracyline Organisms Affected

Humans and other mammals