DM1

DM1 Brand names, DM1 Analogs

DM1 Brand Names Mixture

No information avaliable

DM1 Chemical_Formula

C₂₇H₂₉NO₁₀

DM1 RX_link

http://www.rxlist.com/cgi/generic2/daunorubicin.htm

DM1 fda sheet

http://www.accessdata.fda.gov/scripts/cder/onctools/labels.cfm?GN=daunorubicin,%20daunomycin

DM1 msds (material safety sheet)

DM1 MSDS

DM1 Synthesis Reference

J. P. Parsh et al. J. Pharm. Sci. 56, 1691 (1967);

DM1 Molecular Weight

527.52 g/mol

DM1 Melting Point

208-209 ^oC

DM1 H₂O Solubility

39.2 mg/L

DM1 State

Solid

DM1 LogP

0.766

DM1 Dosage Forms

Powder for solution; Suspension

DM1 Indication

For remission induction in acute nonlymphocytic leukemia (myelogenous, monocytic, erythroid) of adults and for remission induction in acute lymphocytic leukemia of children and adults.

DM1 Pharmacology

Daunorubicin is an antineoplastic in the anthracycline class. General properties of drugs in this class include: interaction with DNA in a variety of different ways including intercalation (squeezing between the base pairs), DNA strand breakage and inhibition with the enzyme topoisomerase II. Most of these compounds have been isolated from natural sources and antibiotics. However, they lack the specificity of the antimicrobial antibiotics and thus produce significant toxicity. The anthracyclines are among the most important antitumor drugs available. Doxorubicin is widely used for the treatment of several solid tumors while daunorubicin and idarubicin are used exclusively for the treatment of leukemia. Daunorubicin may also inhibit polymerase activity, affect regulation of gene expression, and produce free radical damage to DNA. Daunorubicin possesses an antitumor effect against a wide spectrum of tumors, either grafted or spontaneous. The anthracyclines are cell cycle-nonspecific.

DM1 Absorption

No information avaliable

DM1 side effects and Toxicity

LD₅₀=20 mg/kg (mice, IV); LD₅₀=13 mg/kg (rat, IV)

DM1 Patient Information

DM1 Organisms Affected

Humans and other mammals

DM1