Daunarubicinum en es it fr

Daunarubicinum Brand names, Daunarubicinum Analogs

Daunarubicinum Brand Names Mixture

  • No information avaliable

Daunarubicinum Chemical_Formula


Daunarubicinum RX_link


Daunarubicinum fda sheet


Daunarubicinum msds (material safety sheet)

Daunarubicinum MSDS

Daunarubicinum Synthesis Reference

J. P. Parsh et al. J. Pharm. Sci. 56, 1691 (1967);

Daunarubicinum Molecular Weight

527.52 g/mol

Daunarubicinum Melting Point

208-209 oC

Daunarubicinum H2O Solubility

39.2 mg/L

Daunarubicinum State


Daunarubicinum LogP


Daunarubicinum Dosage Forms

Powder for solution; Suspension

Daunarubicinum Indication

For remission induction in acute nonlymphocytic leukemia (myelogenous, monocytic, erythroid) of adults and for remission induction in acute lymphocytic leukemia of children and adults.

Daunarubicinum Pharmacology

Daunorubicin is an antineoplastic in the anthracycline class. General properties of drugs in this class include: interaction with DNA in a variety of different ways including intercalation (squeezing between the base pairs), DNA strand breakage and inhibition with the enzyme topoisomerase II. Most of these compounds have been isolated from natural sources and antibiotics. However, they lack the specificity of the antimicrobial antibiotics and thus produce significant toxicity. The anthracyclines are among the most important antitumor drugs available. Doxorubicin is widely used for the treatment of several solid tumors while daunorubicin and idarubicin are used exclusively for the treatment of leukemia. Daunorubicin may also inhibit polymerase activity, affect regulation of gene expression, and produce free radical damage to DNA. Daunorubicin possesses an antitumor effect against a wide spectrum of tumors, either grafted or spontaneous. The anthracyclines are cell cycle-nonspecific.

Daunarubicinum Absorption

No information avaliable

Daunarubicinum side effects and Toxicity

LD50=20 mg/kg (mice, IV); LD50=13 mg/kg (rat, IV)

Daunarubicinum Patient Information

Daunarubicinum Organisms Affected

Humans and other mammals