Daunarubicinum
Daunarubicinum Brand names, Daunarubicinum Analogs
- Acetyladriamycin
- Anthracyline
- Antibiotics From Streptomyces Coeruleorubidus
- Cerubidin
- Cerubidine
- DM1
- Daunamycin
- Daunarubicinum
- Daunoblastin
- Daunomycin
- Daunomycin Hydrochloride
- Daunomycin, Hydrochloride
- Daunorrubicina
- Daunorubicin Hcl
- Daunorubicin Hydrochloride
- Daunorubicin, Hydrochloride
- Daunorubicine
- Daunorubicinum [Inn-Latin]
- Daunoxome
- Leukaemomycin C
- Ondena
- Rcra Waste No. U059
- Rp 13057 Hydrochloride
- Rubidomycin
- Rubidomycin Hydrochloride
- Rubomycin C
Daunarubicinum Brand Names Mixture
- No information avaliable
Daunarubicinum Chemical_Formula
C27H29NO10
Daunarubicinum RX_link
http://www.rxlist.com/cgi/generic2/daunorubicin.htm
Daunarubicinum fda sheet
Daunarubicinum msds (material safety sheet)
Daunarubicinum Synthesis Reference
J. P. Parsh et al. J. Pharm. Sci. 56, 1691 (1967);
Daunarubicinum Molecular Weight
527.52 g/mol
Daunarubicinum Melting Point
208-209 oC
Daunarubicinum H2O Solubility
39.2 mg/L
Daunarubicinum State
Solid
Daunarubicinum LogP
0.766
Daunarubicinum Dosage Forms
Powder for solution; Suspension
Daunarubicinum Indication
For remission induction in acute nonlymphocytic leukemia (myelogenous, monocytic, erythroid) of adults and for remission induction in acute lymphocytic leukemia of children and adults.
Daunarubicinum Pharmacology
Daunorubicin is an antineoplastic in the anthracycline class. General properties of drugs in this class include: interaction with DNA in a variety of different ways including intercalation (squeezing between the base pairs), DNA strand breakage and inhibition with the enzyme topoisomerase II. Most of these compounds have been isolated from natural sources and antibiotics. However, they lack the specificity of the antimicrobial antibiotics and thus produce significant toxicity. The anthracyclines are among the most important antitumor drugs available. Doxorubicin is widely used for the treatment of several solid tumors while daunorubicin and idarubicin are used exclusively for the treatment of leukemia. Daunorubicin may also inhibit polymerase activity, affect regulation of gene expression, and produce free radical damage to DNA. Daunorubicin possesses an antitumor effect against a wide spectrum of tumors, either grafted or spontaneous. The anthracyclines are cell cycle-nonspecific.
Daunarubicinum Absorption
No information avaliable
Daunarubicinum side effects and Toxicity
LD50=20 mg/kg (mice, IV); LD50=13 mg/kg (rat, IV)
Daunarubicinum Patient Information
Daunarubicinum Organisms Affected
Humans and other mammals
