PharmacyCodes



Daunorubicinum [Inn-Latin] en es it fr

Daunorubicinum [Inn-Latin] Brand names, Daunorubicinum [Inn-Latin] Analogs

Daunorubicinum [Inn-Latin] Brand Names Mixture

  • No information avaliable

Daunorubicinum [Inn-Latin] Chemical_Formula

C27H29NO10

Daunorubicinum [Inn-Latin] RX_link

http://www.rxlist.com/cgi/generic2/daunorubicin.htm

Daunorubicinum [Inn-Latin] fda sheet

http://www.accessdata.fda.gov/scripts/cder/onctools/labels.cfm?GN=daunorubicin,%20daunomycin

Daunorubicinum [Inn-Latin] msds (material safety sheet)

Daunorubicinum_[Inn-Latin] MSDS

Daunorubicinum [Inn-Latin] Synthesis Reference

J. P. Parsh et al. J. Pharm. Sci. 56, 1691 (1967);

Daunorubicinum [Inn-Latin] Molecular Weight

527.52 g/mol

Daunorubicinum [Inn-Latin] Melting Point

208-209 oC

Daunorubicinum [Inn-Latin] H2O Solubility

39.2 mg/L

Daunorubicinum [Inn-Latin] State

Solid

Daunorubicinum [Inn-Latin] LogP

0.766

Daunorubicinum [Inn-Latin] Dosage Forms

Powder for solution; Suspension

Daunorubicinum [Inn-Latin] Indication

For remission induction in acute nonlymphocytic leukemia (myelogenous, monocytic, erythroid) of adults and for remission induction in acute lymphocytic leukemia of children and adults.

Daunorubicinum [Inn-Latin] Pharmacology

Daunorubicin is an antineoplastic in the anthracycline class. General properties of drugs in this class include: interaction with DNA in a variety of different ways including intercalation (squeezing between the base pairs), DNA strand breakage and inhibition with the enzyme topoisomerase II. Most of these compounds have been isolated from natural sources and antibiotics. However, they lack the specificity of the antimicrobial antibiotics and thus produce significant toxicity. The anthracyclines are among the most important antitumor drugs available. Doxorubicin is widely used for the treatment of several solid tumors while daunorubicin and idarubicin are used exclusively for the treatment of leukemia. Daunorubicin may also inhibit polymerase activity, affect regulation of gene expression, and produce free radical damage to DNA. Daunorubicin possesses an antitumor effect against a wide spectrum of tumors, either grafted or spontaneous. The anthracyclines are cell cycle-nonspecific.

Daunorubicinum [Inn-Latin] Absorption

No information avaliable

Daunorubicinum [Inn-Latin] side effects and Toxicity

LD50=20 mg/kg (mice, IV); LD50=13 mg/kg (rat, IV)

Daunorubicinum [Inn-Latin] Patient Information

Daunorubicinum [Inn-Latin] Organisms Affected

Humans and other mammals