Daunorubicin Hcl
Daunorubicin Hcl Brand names, Daunorubicin Hcl Analogs
- Acetyladriamycin
- Anthracyline
- Antibiotics From Streptomyces Coeruleorubidus
- Cerubidin
- Cerubidine
- DM1
- Daunamycin
- Daunarubicinum
- Daunoblastin
- Daunomycin
- Daunomycin Hydrochloride
- Daunomycin, Hydrochloride
- Daunorrubicina
- Daunorubicin Hcl
- Daunorubicin Hydrochloride
- Daunorubicin, Hydrochloride
- Daunorubicine
- Daunorubicinum [Inn-Latin]
- Daunoxome
- Leukaemomycin C
- Ondena
- Rcra Waste No. U059
- Rp 13057 Hydrochloride
- Rubidomycin
- Rubidomycin Hydrochloride
- Rubomycin C
Daunorubicin Hcl Brand Names Mixture
- No information avaliable
Daunorubicin Hcl Chemical_Formula
C27H29NO10
Daunorubicin Hcl RX_link
http://www.rxlist.com/cgi/generic2/daunorubicin.htm
Daunorubicin Hcl fda sheet
Daunorubicin Hcl msds (material safety sheet)
Daunorubicin Hcl Synthesis Reference
J. P. Parsh et al. J. Pharm. Sci. 56, 1691 (1967);
Daunorubicin Hcl Molecular Weight
527.52 g/mol
Daunorubicin Hcl Melting Point
208-209 oC
Daunorubicin Hcl H2O Solubility
39.2 mg/L
Daunorubicin Hcl State
Solid
Daunorubicin Hcl LogP
0.766
Daunorubicin Hcl Dosage Forms
Powder for solution; Suspension
Daunorubicin Hcl Indication
For remission induction in acute nonlymphocytic leukemia (myelogenous, monocytic, erythroid) of adults and for remission induction in acute lymphocytic leukemia of children and adults.
Daunorubicin Hcl Pharmacology
Daunorubicin is an antineoplastic in the anthracycline class. General properties of drugs in this class include: interaction with DNA in a variety of different ways including intercalation (squeezing between the base pairs), DNA strand breakage and inhibition with the enzyme topoisomerase II. Most of these compounds have been isolated from natural sources and antibiotics. However, they lack the specificity of the antimicrobial antibiotics and thus produce significant toxicity. The anthracyclines are among the most important antitumor drugs available. Doxorubicin is widely used for the treatment of several solid tumors while daunorubicin and idarubicin are used exclusively for the treatment of leukemia. Daunorubicin may also inhibit polymerase activity, affect regulation of gene expression, and produce free radical damage to DNA. Daunorubicin possesses an antitumor effect against a wide spectrum of tumors, either grafted or spontaneous. The anthracyclines are cell cycle-nonspecific.
Daunorubicin Hcl Absorption
No information avaliable
Daunorubicin Hcl side effects and Toxicity
LD50=20 mg/kg (mice, IV); LD50=13 mg/kg (rat, IV)
Daunorubicin Hcl Patient Information
Daunorubicin Hcl Organisms Affected
Humans and other mammals
