Daunorubicin Hcl en es it fr

Daunorubicin Hcl Brand names, Daunorubicin Hcl Analogs

Daunorubicin Hcl Brand Names Mixture

  • No information avaliable

Daunorubicin Hcl Chemical_Formula


Daunorubicin Hcl RX_link


Daunorubicin Hcl fda sheet


Daunorubicin Hcl msds (material safety sheet)

Daunorubicin_Hcl MSDS

Daunorubicin Hcl Synthesis Reference

J. P. Parsh et al. J. Pharm. Sci. 56, 1691 (1967);

Daunorubicin Hcl Molecular Weight

527.52 g/mol

Daunorubicin Hcl Melting Point

208-209 oC

Daunorubicin Hcl H2O Solubility

39.2 mg/L

Daunorubicin Hcl State


Daunorubicin Hcl LogP


Daunorubicin Hcl Dosage Forms

Powder for solution; Suspension

Daunorubicin Hcl Indication

For remission induction in acute nonlymphocytic leukemia (myelogenous, monocytic, erythroid) of adults and for remission induction in acute lymphocytic leukemia of children and adults.

Daunorubicin Hcl Pharmacology

Daunorubicin is an antineoplastic in the anthracycline class. General properties of drugs in this class include: interaction with DNA in a variety of different ways including intercalation (squeezing between the base pairs), DNA strand breakage and inhibition with the enzyme topoisomerase II. Most of these compounds have been isolated from natural sources and antibiotics. However, they lack the specificity of the antimicrobial antibiotics and thus produce significant toxicity. The anthracyclines are among the most important antitumor drugs available. Doxorubicin is widely used for the treatment of several solid tumors while daunorubicin and idarubicin are used exclusively for the treatment of leukemia. Daunorubicin may also inhibit polymerase activity, affect regulation of gene expression, and produce free radical damage to DNA. Daunorubicin possesses an antitumor effect against a wide spectrum of tumors, either grafted or spontaneous. The anthracyclines are cell cycle-nonspecific.

Daunorubicin Hcl Absorption

No information avaliable

Daunorubicin Hcl side effects and Toxicity

LD50=20 mg/kg (mice, IV); LD50=13 mg/kg (rat, IV)

Daunorubicin Hcl Patient Information

Daunorubicin Hcl Organisms Affected

Humans and other mammals