Daunorubicine en es it fr

Daunorubicine Brand names, Daunorubicine Analogs

Daunorubicine Brand Names Mixture

  • No information avaliable

Daunorubicine Chemical_Formula


Daunorubicine RX_link


Daunorubicine fda sheet


Daunorubicine msds (material safety sheet)

Daunorubicine MSDS

Daunorubicine Synthesis Reference

J. P. Parsh et al. J. Pharm. Sci. 56, 1691 (1967);

Daunorubicine Molecular Weight

527.52 g/mol

Daunorubicine Melting Point

208-209 oC

Daunorubicine H2O Solubility

39.2 mg/L

Daunorubicine State


Daunorubicine LogP


Daunorubicine Dosage Forms

Powder for solution; Suspension

Daunorubicine Indication

For remission induction in acute nonlymphocytic leukemia (myelogenous, monocytic, erythroid) of adults and for remission induction in acute lymphocytic leukemia of children and adults.

Daunorubicine Pharmacology

Daunorubicin is an antineoplastic in the anthracycline class. General properties of drugs in this class include: interaction with DNA in a variety of different ways including intercalation (squeezing between the base pairs), DNA strand breakage and inhibition with the enzyme topoisomerase II. Most of these compounds have been isolated from natural sources and antibiotics. However, they lack the specificity of the antimicrobial antibiotics and thus produce significant toxicity. The anthracyclines are among the most important antitumor drugs available. Doxorubicin is widely used for the treatment of several solid tumors while daunorubicin and idarubicin are used exclusively for the treatment of leukemia. Daunorubicin may also inhibit polymerase activity, affect regulation of gene expression, and produce free radical damage to DNA. Daunorubicin possesses an antitumor effect against a wide spectrum of tumors, either grafted or spontaneous. The anthracyclines are cell cycle-nonspecific.

Daunorubicine Absorption

No information avaliable

Daunorubicine side effects and Toxicity

LD50=20 mg/kg (mice, IV); LD50=13 mg/kg (rat, IV)

Daunorubicine Patient Information

Daunorubicine Organisms Affected

Humans and other mammals