Daunorrubicina en es it fr

Daunorrubicina Brand names, Daunorrubicina Analogs

Daunorrubicina Brand Names Mixture

  • No information avaliable

Daunorrubicina Chemical_Formula


Daunorrubicina RX_link


Daunorrubicina fda sheet


Daunorrubicina msds (material safety sheet)

Daunorrubicina MSDS

Daunorrubicina Synthesis Reference

J. P. Parsh et al. J. Pharm. Sci. 56, 1691 (1967);

Daunorrubicina Molecular Weight

527.52 g/mol

Daunorrubicina Melting Point

208-209 oC

Daunorrubicina H2O Solubility

39.2 mg/L

Daunorrubicina State


Daunorrubicina LogP


Daunorrubicina Dosage Forms

Powder for solution; Suspension

Daunorrubicina Indication

For remission induction in acute nonlymphocytic leukemia (myelogenous, monocytic, erythroid) of adults and for remission induction in acute lymphocytic leukemia of children and adults.

Daunorrubicina Pharmacology

Daunorubicin is an antineoplastic in the anthracycline class. General properties of drugs in this class include: interaction with DNA in a variety of different ways including intercalation (squeezing between the base pairs), DNA strand breakage and inhibition with the enzyme topoisomerase II. Most of these compounds have been isolated from natural sources and antibiotics. However, they lack the specificity of the antimicrobial antibiotics and thus produce significant toxicity. The anthracyclines are among the most important antitumor drugs available. Doxorubicin is widely used for the treatment of several solid tumors while daunorubicin and idarubicin are used exclusively for the treatment of leukemia. Daunorubicin may also inhibit polymerase activity, affect regulation of gene expression, and produce free radical damage to DNA. Daunorubicin possesses an antitumor effect against a wide spectrum of tumors, either grafted or spontaneous. The anthracyclines are cell cycle-nonspecific.

Daunorrubicina Absorption

No information avaliable

Daunorrubicina side effects and Toxicity

LD50=20 mg/kg (mice, IV); LD50=13 mg/kg (rat, IV)

Daunorrubicina Patient Information

Daunorrubicina Organisms Affected

Humans and other mammals