Daunamycin en es it fr

Daunamycin Brand names, Daunamycin Analogs

Daunamycin Brand Names Mixture

  • No information avaliable

Daunamycin Chemical_Formula


Daunamycin RX_link


Daunamycin fda sheet


Daunamycin msds (material safety sheet)

Daunamycin MSDS

Daunamycin Synthesis Reference

J. P. Parsh et al. J. Pharm. Sci. 56, 1691 (1967);

Daunamycin Molecular Weight

527.52 g/mol

Daunamycin Melting Point

208-209 oC

Daunamycin H2O Solubility

39.2 mg/L

Daunamycin State


Daunamycin LogP


Daunamycin Dosage Forms

Powder for solution; Suspension

Daunamycin Indication

For remission induction in acute nonlymphocytic leukemia (myelogenous, monocytic, erythroid) of adults and for remission induction in acute lymphocytic leukemia of children and adults.

Daunamycin Pharmacology

Daunorubicin is an antineoplastic in the anthracycline class. General properties of drugs in this class include: interaction with DNA in a variety of different ways including intercalation (squeezing between the base pairs), DNA strand breakage and inhibition with the enzyme topoisomerase II. Most of these compounds have been isolated from natural sources and antibiotics. However, they lack the specificity of the antimicrobial antibiotics and thus produce significant toxicity. The anthracyclines are among the most important antitumor drugs available. Doxorubicin is widely used for the treatment of several solid tumors while daunorubicin and idarubicin are used exclusively for the treatment of leukemia. Daunorubicin may also inhibit polymerase activity, affect regulation of gene expression, and produce free radical damage to DNA. Daunorubicin possesses an antitumor effect against a wide spectrum of tumors, either grafted or spontaneous. The anthracyclines are cell cycle-nonspecific.

Daunamycin Absorption

No information avaliable

Daunamycin side effects and Toxicity

LD50=20 mg/kg (mice, IV); LD50=13 mg/kg (rat, IV)

Daunamycin Patient Information

Daunamycin Organisms Affected

Humans and other mammals